Corlanor

Corlanor is used in certain people who have chronic heart failure. It is used in combination with a beta-blocker.

Corlanor Overview

Reviewed: April 16, 2015
Updated: 

Corlanor is a prescription medication used to treat long-lasting heart failure in patients who are stable and have a resting heart rate of at least 70 beats per minute. Patients must also be taking a beta-blocker at the highest dose they can tolerate.

Corlanor belongs to a group of drugs called hyperpolarization-activated cyclic nucleotide-gated channel blockers. Corlanor regulates the pacemaker activity of the heart.

This medication comes in tablet form and is taken 2 times a day, with meals.

Common side effects of Corlanor include slow heart rate, high blood pressure, irregular heartbeat, and seeing flashes of light.

Corlanor can also cause dizziness. Do not drive or operate heavy machinery until you know how Corlanor affects you.

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Corlanor Cautionary Labels

precautionsprecautions

Uses of Corlanor

Corlanor is a prescription medication used to treat long-lasting heart failure in patients who are stable and have a resting heart rate of at least 70 beats per minute. Patients must also be taking a beta-blocker at the highest dose they can tolerate.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Corlanor Drug Class

Corlanor is part of the drug class:

Side Effects of Corlanor

Serious side effects have been reported with Corlanor. See the “Corlanor Precautions” section.

Common side effects of Corlanor include the following:

  • slow heart rate
  • high blood pressure
  • irregular heartbeat, including atrial fibrillation
  • visual disturbances, including flashes of light

This is not a complete list of Corlanor side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Corlanor Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • CYP3A4 inhibitors such as itraconazole (Onmel, Sporanox), clarithromycin (Biaxin), telithromycin (Ketek), nelfinavir (Viracept), and nefazodone (Serzone)
  • CYP3A4 inducers such as rifampin (Rifadin), carbamazepine (Tegretol, Carbatrol), diltiazem (Cardizem, Dilt-cd), phenobarbital, phenytoin (Dilantin, Phenytek), verapamil (Calan, Covera-HS, Verelan), and St. John's wort

This is not a complete list of Corlanor drug interactions. Ask your doctor or pharmacist for more information.

Corlanor Precautions

Serious side effects have been reported with Corlanor including the following:

  • Increased risk of irregular heartbeat (atrial fibrillation or heart rhythm problems). Tell your doctor if you have symptoms of an irregular heartbeat, such as feeling that your heart is pounding or racing (palpitations), chest pressure, or worsened shortness of breath.
  • Low heart rate (bradycardia). Tell your doctor if you have a slowing of your heart rate or if you have symptoms of a low heart rate such as dizziness, fatigue, lack of energy, or have low blood pressure. Low heart rate is a common side effect of Corlanor and can be serious.

Corlanor can cause dizziness. Do not drive or operate heavy machinery until you know how Corlanor affects you.

Do not take Corlanor if you:

  • are allergic to Corlanor or to any of its ingredients
  • have symptoms of heart failure that recently worsened
  • have low blood pressure (less than 90/50 mmHg)
  • have certain heart conditions called sick sinus syndrome, sinoatrial block, or 3rd degree atrioventricular block
  • have a resting heart rate lower than 60 beats per minute
  • have severe liver disease
  • have pacemaker dependence
  • are using other medications that are strong inhibitors of enzymes that metabolize Corlanor

Corlanor Food Interactions

Grapefruit and grapefruit juice may interact with Corlanor and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Inform MD

Before taking Corlanor, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

are allergic to Corlanor or to any of its ingredients

  • have liver problems
  • have heart problems
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Corlanor and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

Corlanor may cause harm to an unborn baby. You should not become pregnant while taking Corlanor. Women who are able to get pregnant must use birth control when taking Corlanor. If you become pregnant while taking Corlanor, tell your doctor right away.

Corlanor and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Corlanor crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Women who are taking Corlanor should not breastfeed.

Corlanor Usage

Take Corlanor exactly as prescribed.

This medication comes in tablet form and is taken 2 times a day, with meals.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Corlanor at the same time.

Corlanor Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication

The recommended dose/dose range of Corlanor is 5 mg twice daily for 2 weeks. After 2 weeks, the dose is adjusted on the basis of heart rate and response to the drug. The maximum dose of Corlanor is 7.5 mg twice daily.

Corlanor Overdose

If you take too much Corlanor, call your healthcare provider or local Poison Control Center or seek emergency medical attention right away.

If Corlanor is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Corlanor at room temperature.
  • Keep this and all medications out of the reach of children.