Colchicine

Colchicine is used to prevent gout attacks and treat the pain of gout attacks when they occur. It is also used to treat familial Mediterranean fever.

Colchicine Overview

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Colchicine is a prescription medication used to prevent and treat gout attacks and familial Mediterranean fever (FMF). Colchicine belongs to a group of drugs called antigout agents. It is thought to work by inhibiting the activity of neutrophils (inflammatory cells), which results in the reduction of inflammation and the symptoms of gout.

Colchicine comes in tablet and capsule form and is usually taken once or twice daily.
 
Common side effects of colchicine include nausea, vomiting, and diarrhea.

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  • Other
  • Amyloidosis
  • Familial Mediterranean Fever
  • Gout
  • Liver Cirrhosis, Biliary

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Colchicine Cautionary Labels

precautionsprecautions

Uses of Colchicine

Colchicine is a prescription medicine used to:

  • prevent and treat gout flares in adults
  • treat familial Mediterranean fever (FMF) in adults and children age four or older.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Colchicine Brand Names

Colchicine may be found in some form under the following brand names:

Colchicine Drug Class

Colchicine is part of the drug class:

Side Effects of Colchicine

Colchicine can cause serious side effects or even cause death. Get medical help right away, if you have:

  • Muscle weakness or pain
  • Numbness or tingling in your fingers or toes
  • Unusual bleeding or bruising
  • Increased infections
  • Feel weak or tired
  • Pale or gray color to your lips, tongue, or palms of your hands
  • Severe diarrhea or vomiting

Gout Flares: The most common side effect of colchicine in people who have gout flares is diarrhea.

FMF: The most common side effects of colchicine in people who have FMF are abdominal pain, diarrhea, nausea and vomiting.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of colchicine. For more information, ask your healthcare provider or pharmacist.

Colchicine Interactions

Tell your doctor about all the medicines you take, including ones that you may only be taking for a short time, such as antibiotics.  Especially tell your doctor if you are taking:

  • atazanavir sulfate (Reyataz)
  • clarithromycin (Biaxin)
  • cyclosporine (Neoral, Gengraf, Sandimmune)
  • darunavir (Prezista)
  • fosamprenavir (Lexiva) with ritonavir
  • fosamprenavir (Lexiva)
  • indinavir (Crixivan)
  • itraconazole (Sporanox)
  • ketoconazole (Nizoral)
  • Iopinavir/ritonavir (Kaletra)
  • nefazodone (Serzone)
  • nelfinavir mesylate(Viracept)
  • ritonavir (Norvir)
  • saquinavir mesylate (Invirase)
  • telithromycin (Ketek)
  • tipranavir (Aptivus)

Do not start a new medicine without talking to your doctor.

This is not a complete list of colchicine drug interactions.  Ask your doctor or pharmacist for more information.

Colchicine Precautions

Colchicine can cause serious side effects or death if levels of colchicine are too high in your body.

  • Taking certain medicines with colchicine can cause your level of colchicine to be too high, especially if you have kidney or liver problems.
  • Tell your doctor about all your medical conditions, including if you have kidney or liver problems. Your dose of colchicine may need to be changed.
  • Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements.
  • Even medicines that you take for a short period of time, such as antibiotics, can interact with colchicine and cause serious side effects or death.
  • Talk to your doctor or pharmacist before takng any new medicine.
  • See "Drug Interactions"

Do not take colchicine if you have liver or kidney problems and you take certain other medicines. Serious side effects, including death, have been reported in these patients even when taken as directed.

Colchicine Food Interactions

Avoid eating grapefruit or drinking grapefruit juice while taking colchicine. It can increase your chances of getting serious side effects.

Inform MD

Before you take colchicine tell your doctor about all your medical conditions including if you:

  • have liver or kidney problems
  • are pregnant or plan to become pregnant. It is not known if colchicine will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. Colchicine passes into your breast milk. You and your doctor should decide if you will take colchicine or breastfeed. If you take colchicine and breastfeed, you should talk to your child's doctor about how to watch for side effects in your child.

Tell your doctor about all the medicines you take, including ones that you may only be taking for a short time, such as antibiotics. Do not start a new medicine without talking to your doctor. Using colchicine with certain other medicines, such as cholesterol-lowering medications and digoxin, can affect each other causing serious side effects. Your doctor may need to change your dose of colchicine. Talk to your doctor about whether the medications you are taking might interact with colchicine, and what side effects to look for.

Colchicine and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Colchicine and Lactation

Tell your doctor if you are breastfeeding or if you plan to breastfeed. Colchicine is excreted in human breast milk. It is not known if colchicine will harm your baby.

Colchicine Usage

  • Take colchicine exactly as your healthcare provider tells you to take it. If you are not sure about your dosing, call your healthcare provider.
  • Colchicine can be taken with or without food.
  • If you take too much colchicine go to the nearest hospital emergency room right away.
  • Do not stop taking colchicine even if you start to feel better, unless your healthcare provider tells you.
  • Your healthcare provider may do blood tests while you take colchicine.
  • If you take colchicine daily and you miss a dose, then take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take 2 doses at the same time.
  • If you have a gout flare while taking colchicine daily, report this to your healthcare provider.

Colchicine Dosage

Take colchicine exactly as your doctor prescribes it. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you.

Gout flares

  •   Gout flare  Prevention: Typical dose is 0.6 mg (1 tablet or 1 capsule ) once or twice daily in patients over 16 years of age.  Maximum daily dose is 1.2 mg (2 tablets or 2 capsules) per day.

  • Gout flare Treatment (Colcrys only): Typical dose is 1.2 mg (2 tablets) at the first sign of a gout flare followed by 0.6 mg (1 tablet) one hour later.

Familial Mediterranean fever (FMF) (Colcrys only): 

  • 12 years or older: Typical dose is 1.2 to 2.4 mg (2 to 4 tablets) given in one or two divided doses.
  • 6 to 12 years old: Typical dose is 0.9 to 1.8 mg (1 & 1/2 to 3 tablets) given in one or two divided doses.
  • 4 to 6 years old: Typical dose is 0.3 to 1.8 mg (1/2 to 3 tablets) given in one or two divided doses.

Colchicine Overdose

If you take too much colchicine call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If colchicine is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Keep colchicine tablets at controlled room temperature.
  • Keep colchicine capsules at 20° to 25°C (68° to 77°F).
  • Keep colchicine in tightly sealed container, out of the light.
  • Keep this and all medicines out of the reach of children.