VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus
Overview[ - collapse ][ - ]
| Purpose | The purpose of this study is to determine whether the initiation of a vildagliptin plus metformin combination regimen would result in more durable glycemic control than metformin monotherapy in treatment-naïve patients with T2DM. |
|---|---|
| Condition | Type 2 Diabetes Mellitus |
| Intervention | Drug: Placebo to vildagliptin Drug: vildagliptin Drug: Metformin |
| Phase | Phase 4 |
| Sponsor | Novartis Pharmaceuticals |
| Responsible Party | Novartis |
| ClinicalTrials.gov Identifier | NCT01528254 |
| First Received | February 3, 2012 |
| Last Updated | May 21, 2013 |
| Last verified | May 2013 |
Tracking Information[ + expand ][ + ]
| First Received Date | February 3, 2012 |
|---|---|
| Last Updated Date | May 21, 2013 |
| Start Date | January 2012 |
| Estimated Primary Completion Date | February 2019 |
| Current Primary Outcome Measures |
|
| Current Secondary Outcome Measures |
|
Descriptive Information[ + expand ][ + ]
| Brief Title | VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus |
|---|---|
| Official Title | A 5-year Study to Compare the Durability of Glycemic Control of a Combination Regimen With Vildagliptin & Metformin Versus Standard-of-care Monotherapy With Metformin, Initiated in Treatment-naïve Patients With Type 2 Diabetes Mellitus |
| Brief Summary | The purpose of this study is to determine whether the initiation of a vildagliptin plus metformin combination regimen would result in more durable glycemic control than metformin monotherapy in treatment-naïve patients with T2DM. |
| Detailed Description | Not Provided |
| Study Type | Interventional |
| Study Phase | Phase 4 |
| Study Design | Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment |
| Condition | Type 2 Diabetes Mellitus |
| Intervention | Drug: Placebo to vildagliptin Drug: vildagliptin Patients will be instructed to take one tablet (50 mg oral) of vildagliptin in the morning and one tablet in the evening with or without food. Other Names: LAF237Drug: Metformin Metformin should be taken in a twice daily (bid) regimen during or after meals at the same time as vildagliptin. |
| Study Arm (s) |
|
Recruitment Information[ + expand ][ + ]
| Recruitment Status | Recruiting |
|---|---|
| Estimated Enrollment | 2000 |
| Estimated Completion Date | February 2019 |
| Estimated Primary Completion Date | February 2019 |
| Eligibility Criteria | Inclusion Criteria: - Type 2 Diabetes Mellitus (T2DM) diagnosed ≤ 24 months ago - glycosylated hemoglobin (HbA1c) ≥6.5% and ≤7.5% at Visit 1 - Treatment-naïve. - Body mass index (BMI) ≥22 and ≤40 kg/m2 at Visit 1 Exclusion Criteria: - Pregnant or nursing (lactating) women - Fasting plasma glucose (FPG) ≥ 270 mg/dL (≥ 15.0 mmol/L) - Previous or current participation in any vildagliptin clinical study. - History of hypersensitivity to dipeptidyl peptidase-4 (DPP-4) inhibitors. - Concurrent medical condition that may interfere with the interpretation of efficacy and safety data during the study. - Donation of blood or significant blood loss equaling to at least one unit of blood within the past 2 weeks of start of study or a blood transfusion within the past 12 weeks or planned regular transfusions during the study period Other protocol-defined inclusion/exclusion criteria may apply |
| Gender | Both |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Contact: Novartis Pharmaceuticals +41613241111 |
| Location Countries | Argentina, Australia, Austria, Brazil, Bulgaria, Canada, Colombia, Costa Rica, Czech Republic, Dominican Republic, Ecuador, Estonia, Finland, Germany, Guatemala, Hong Kong, Hungary, India, Israel, Italy, Korea, Republic of, Latvia, Lithuania, Malaysia, Mexico, Norway, Panama, Peru, Philippines, Poland, Romania, Russian Federation, Slovakia, South Africa, Taiwan, Turkey |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01528254 |
|---|---|
| Other Study ID Numbers | CLAF237A23156 |
| Has Data Monitoring Committee | Not Provided |
| Information Provided By | Novartis |
| Study Sponsor | Novartis Pharmaceuticals |
| Collaborators | Not Provided |
| Investigators | Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals |
| Verification Date | May 2013 |
Locations[ + expand ][ + ]
| Novartis Investigative Site | Rosario, Santa Fe, Argentina, S2000AII Recruiting |
|---|---|
| Novartis Investigative Site | Buenos Aires, Argentina, C1425AGC Recruiting |
| Novartis Investigative Site | Buenos Aires, Argentina, C1056ABJ Recruiting |
| Novartis Investigative Site | Buenos Aires, Argentina, B1642DCD Recruiting |
| Novartis Investigative Site | Buenos aires, Argentina, C1120AAC Recruiting |
| Novartis Investigative Site | Capital Federal, Argentina, C1179AAB Recruiting |
| Novartis Investigative Site | Cordoba, Argentina, X5000AAW Recruiting |
| Novartis Investigative Site | Corrientes, Argentina, W3410AVV Recruiting |
| Novartis Investigative Site | Brookvale, New South Wales, Australia, 2100 Recruiting |
| Novartis Investigative Site | Manly, New South Wales, Australia, 2095 Recruiting |
| Novartis Investigative Site | Woy Woy, New South Wales, Australia, 2256 Recruiting |
| Novartis Investigative Site | Mermaid Beach, Queensland, Australia, 4218 Recruiting |
| Novartis Investigative Site | Morayfield, Queensland, Australia, 4506 Recruiting |
| Novartis Investigative Site | Linz, Austria, 4021 Not yet recruiting |
| Novartis Investigative Site | Salzburg, Austria, A-5020 Not yet recruiting |
| Novartis Investigative Site | Wien, Austria, 1090 Not yet recruiting |
| Novartis Investigative Site | Wien, Austria, A-1130 Not yet recruiting |
| Novartis Investigative Site | Fortaleza, CE, Brazil, 60430-140 Not yet recruiting |
| Novartis Investigative Site | Fortaleza, CE, Brazil, 60170-320 Not yet recruiting |
| Novartis Investigative Site | Brasilia, DF, Brazil, 71625-009 Not yet recruiting |
| Novartis Investigative Site | Goiania, GO, Brazil, 74935-530 Not yet recruiting |
| Novartis Investigative Site | Belem, PA, Brazil, 66073-000 Not yet recruiting |
| Novartis Investigative Site | Curitiba, PR, Brazil, 80810-040 Not yet recruiting |
| Novartis Investigative Site | Porto Alegre, RS, Brazil, 90035-170 Not yet recruiting |
| Novartis Investigative Site | Mogi das Cruzes, SP, Brazil, 08780-090 Not yet recruiting |
| Novartis Investigative Site | São Paulo, SP, Brazil, 01244-030 Not yet recruiting |
| Novartis Investigative Site | São Paulo, SP, Brazil, 04023-900 Not yet recruiting |
| Novartis Investigative Site | São Paulo, SP, Brazil, 05403-000 Not yet recruiting |
| Novartis Investigative Site | São Paulo, SP, Brazil, 01224-000 Not yet recruiting |
| Novartis Investigative Site | Gabrovo, Bulgaria, 5300 Not yet recruiting |
| Novartis Investigative Site | Kazanlak, Bulgaria, 6100 Recruiting |
| Novartis Investigative Site | Plovdiv, Bulgaria, 4002 Recruiting |
| Novartis Investigative Site | Razgrad, Bulgaria Recruiting |
| Novartis Investigative Site | Ruse, Bulgaria, 7200 Not yet recruiting |
| Novartis Investigative Site | Smolian, Bulgaria, 4700 Recruiting |
| Novartis Investigative Site | Sofia, Bulgaria Recruiting |
| Novartis Investigative Site | Sofia, Bulgaria, 1606 Withdrawn |
| Novartis Investigative Site | Sofia, Bulgaria, 1606 Recruiting |
| Novartis Investigative Site | Sofia, Bulgaria, 1431 Recruiting |
| Novartis Investigative Site | Calgary, Alberta, Canada, T2H 2G4 Withdrawn |
| Novartis Investigative Site | Spruce Grove, Alberta, Canada, T7X 2V2 Withdrawn |
| Novartis Investigative Site | Langley, British Columbia, Canada, V3A 4H9 Withdrawn |
| Novartis Investigative Site | Winnipeg, Manitoba, Canada, R2V 4W3 Withdrawn |
| Novartis Investigative Site | Winnipeg, Manitoba, Canada, R3E 3P4 Withdrawn |
| Novartis Investigative Site | Moncton, New Brunswick, Canada, E1G 1A7 Withdrawn |
| Novartis Investigative Site | St. John's, Newfoundland and Labrador, Canada, A1A 3R5 Withdrawn |
| Novartis Investigative Site | Halifax, Nova Scotia, Canada, B3K 2M5 Withdrawn |
| Novartis Investigative Site | Brampton, Ontario, Canada, L6S 0C9 Withdrawn |
| Novartis Investigative Site | Toronto, Ontario, Canada, M9V 4B4 Withdrawn |
| Novartis Investigative Site | Toronto, Ontario, Canada, M4G 3E8 Withdrawn |
| Novartis Investigative Site | Drummondville, Quebec, Canada, J2B 7T1 Withdrawn |
| Novartis Investigative Site | Gatineau, Quebec, Canada, J8Y 6S8 Withdrawn |
| Novartis Investigative Site | Mirabel, Quebec, Canada, J7J 2K8 Withdrawn |
| Novartis Investigative Site | Sherbrooke, Quebec, Canada, J1G 5K2 Withdrawn |
| Novartis Investigative Site | St-Romuald, Quebec, Canada, G6W 5M6 Withdrawn |
| Novartis Investigative Site | Ste-Foy, Quebec, Canada, G1W 4R4 Withdrawn |
| Novartis Investigative Site | Victoriaville, Quebec, Canada, G6P 6P6 Withdrawn |
| Novartis Investigative Site | Quebec, Canada, G3K 2P8 Withdrawn |
| Novartis Investigative Site | Cartagena, Bolivar, Colombia Recruiting |
| Novartis Investigative Site | Bogota, Cundinamarca, Colombia Not yet recruiting |
| Novartis Investigative Site | Baranquilla, Colombia Recruiting |
| Novartis Investigative Site | Bogotá, Colombia Withdrawn |
| Novartis Investigative Site | Bogotá, Colombia Recruiting |
| Novartis Investigative Site | Cartago, Costa Rica, 75-100 Withdrawn |
| Novartis Investigative Site | San Pedro, Costa Rica, 1406-1200 Withdrawn |
| Novartis Investigative Site | Brandys Nad Labem, Czech Republic, 250 01 Not yet recruiting |
| Novartis Investigative Site | Moravska Ostrava, Czech Republic, 702 00 Not yet recruiting |
| Novartis Investigative Site | Ostrava, Czech Republic, 709 00 Not yet recruiting |
| Novartis Investigative Site | Pisek, Czech Republic, 397 01 Not yet recruiting |
| Novartis Investigative Site | Prague 5, Czech Republic, 150 30 Not yet recruiting |
| Novartis Investigative Site | Praha, Czech Republic, 149 01 Not yet recruiting |
| Novartis Investigative Site | Santo Domingo, Republica Dominicana, Dominican Republic Recruiting |
| Novartis Investigative Site | Santo Domingo, Dominican Republic Recruiting |
| Novartis Investigative Site | Quito, Pichincha, Ecuador Not yet recruiting |
| Novartis Investigative Site | Quito, Ecuador Not yet recruiting |
| Novartis Investigative Site | Saku, Estonia, 75501 Recruiting |
| Novartis Investigative Site | Tallinn, Estonia, 13415 Recruiting |
| Novartis Investigative Site | Tallinn, Estonia, 10117 Recruiting |
| Novartis Investigative Site | Tallinn, Estonia, 11911 Recruiting |
| Novartis Investigative Site | Tallinn, Estonia, 13419 Recruiting |
| Novartis Investigative Site | Lahti, Suomi, Finland, 15110 Recruiting |
| Novartis Investigative Site | Helsinki, Finland, 00930 Withdrawn |
| Novartis Investigative Site | Joensuu, Finland, 80100 Recruiting |
| Novartis Investigative Site | Kerava, Finland, 04200 Recruiting |
| Novartis Investigative Site | Kokkola, Finland, 67100 Recruiting |
| Novartis Investigative Site | Kouvola, Finland, 45100 Recruiting |
| Novartis Investigative Site | Kuopio, Finland, 70211 Not yet recruiting |
| Novartis Investigative Site | Oulu, Finland, 90100 Recruiting |
| Novartis Investigative Site | Seinajoki, Finland, FIN-60220 Recruiting |
| Novartis Investigative Site | Tampere, Finland, 33100 Recruiting |
| Novartis Investigative Site | Turku, Finland, FIN-20100 Withdrawn |
| Novartis Investigative Site | Aschaffenburg, Germany, 63739 Recruiting |
| Novartis Investigative Site | Bernkastel-Kues, Germany, 54470 Recruiting |
| Novartis Investigative Site | Duesseldorf, Germany, 40225 Recruiting |
| Novartis Investigative Site | Essen, Germany, 45276 Recruiting |
| Novartis Investigative Site | Esslingen am Neckar, Germany, 73728 Recruiting |
| Novartis Investigative Site | Frankfurt Bergen Enkheim, Germany, 60388 Recruiting |
| Novartis Investigative Site | Fulda, Germany, 36037 Recruiting |
| Novartis Investigative Site | Gelnhausen, Germany, 63571 Recruiting |
| Novartis Investigative Site | Heilbronn, Germany, 74076 Recruiting |
| Novartis Investigative Site | Kamp-Lintfort, Germany, 47475 Recruiting |
| Novartis Investigative Site | Koeln, Germany, 51069 Recruiting |
| Novartis Investigative Site | Ludwigshafen, Germany, 67059 Recruiting |
| Novartis Investigative Site | Mannheim, Germany, 68159 Recruiting |
| Novartis Investigative Site | Neuwied, Germany, 56564 Recruiting |
| Novartis Investigative Site | St. Ingbert - Oberwuerzbach, Germany, 66386 Recruiting |
| Novartis Investigative Site | Viernheim, Germany, 68519 Recruiting |
| Novartis Investigative Site | Wangen, Germany, 88239 Recruiting |
| Novartis Investigative Site | Guatemala City, Guatemala, 01010 Recruiting |
| Novartis Investigative Site | Guatemala City, Guatemala, 01014 Recruiting |
| Novartis Investigative Site | Guatemala City, Guatemala, 010014 Not yet recruiting |
| Novartis Investigative Site | Guatemala City, Guatemala, 010011 Not yet recruiting |
| Novartis Investigative Site | Hong Kong, Hong Kong Recruiting |
| Novartis Investigative Site | Hong Kong, Hong Kong Withdrawn |
| Novartis Investigative Site | Hong Kong, Hong Kong Not yet recruiting |
| Novartis Investigative Site | HongKong, Hong Kong Recruiting |
| Novartis Investigative Site | Bekescsaba, Hungary, H-5600 Withdrawn |
| Novartis Investigative Site | Budapest, Hungary, 1097 Not yet recruiting |
| Novartis Investigative Site | Budapest, Hungary, 1212 Recruiting |
| Novartis Investigative Site | Budapest, Hungary, 1139 Withdrawn |
| Novartis Investigative Site | Budapest, Hungary, 1138 Recruiting |
| Novartis Investigative Site | Csongrad, Hungary, 6640 Recruiting |
| Novartis Investigative Site | Eger, Hungary, H-3300 Recruiting |
| Novartis Investigative Site | Erd, Hungary, 2030 Withdrawn |
| Novartis Investigative Site | Kalocsa, Hungary, 6300 Not yet recruiting |
| Novartis Investigative Site | Kecskemet, Hungary, 6001 Not yet recruiting |
| Novartis Investigative Site | Szeged, Hungary, H-6720 Recruiting |
| Novartis Investigative Site | Veszprem, Hungary, H-8200 Recruiting |
| Novartis Investigative Site | Zalaegerszeg, Hungary, 8900 Recruiting |
| Novartis Investigative Site | New Delhi, Delhi, India, 110076 Recruiting |
| Novartis Investigative Site | Bangalore, Karnataka, India, 560034 Recruiting |
| Novartis Investigative Site | Bangalore, Karnataka, India, 560003 Recruiting |
| Novartis Investigative Site | Bangalore, Karnataka, India, 560 043 Recruiting |
| Novartis Investigative Site | Kochi, Kerala, India, 682041 Recruiting |
| Novartis Investigative Site | Indore, Madhya Pradesh, India, 452010 Recruiting |
| Novartis Investigative Site | Pune, Maharashtra, India, 411 005 Recruiting |
| Novartis Investigative Site | Pune, Maharashtra, India, 411011 Recruiting |
| Novartis Investigative Site | Jaipur, Rajasthan, India, 302023 Recruiting |
| Novartis Investigative Site | Jaipur, Rajasthan, India, 302015 Recruiting |
| Novartis Investigative Site | Chennai, Tamil Nadu, India, 600 086 Recruiting |
| Novartis Investigative Site | Chennai, Tamilnadu, India, 600008 Recruiting |
| Novartis Investigative Site | Lucknow, Uttar Pradesh, India, 226003 Withdrawn |
| Novartis Investigative Site | Chandigarh, India, 160 012 Recruiting |
| Novartis Investigative Site | Heifa, Israel Recruiting |
| Novartis Investigative Site | Herzelia, Israel Not yet recruiting |
| Novartis Investigative Site | Kfar-Sava, Israel, 44281 Recruiting |
| Novartis Investigative Site | Ramla, Israel Withdrawn |
| Novartis Investigative Site | Rehovot, Israel, 76100 Recruiting |
| Novartis Investigative Site | Safed, Israel, 13100 Recruiting |
| Novartis Investigative Site | Tel Giborim, Holon, Israel, 58100 Recruiting |
| Novartis Investigative Site | Montichiari, BS, Italy, 25018 Recruiting |
| Novartis Investigative Site | Campobasso, CB, Italy, 86100 Recruiting |
| Novartis Investigative Site | Firenze, FI, Italy, 50134 Recruiting |
| Novartis Investigative Site | Arenzano, GE, Italy, 16011 Recruiting |
| Novartis Investigative Site | Milano, MI, Italy, 20157 Recruiting |
| Novartis Investigative Site | Milano, MI, Italy, 20132 Recruiting |
| Novartis Investigative Site | Casorate Primo, PV, Italy, 27022 Recruiting |
| Novartis Investigative Site | Roma, RM, Italy, 00133 Recruiting |
| Novartis Investigative Site | Roma, RM, Italy, 00161 Recruiting |
| Novartis Investigative Site | Mercato San Severino, SA, Italy, 84085 Recruiting |
| Novartis Investigative Site | Bucheon, Gyeonggi-do, Korea, Republic of, 424-717 Recruiting |
| Novartis Investigative Site | Suwon, Gyeonggi-do, Korea, Republic of, 442-723 Recruiting |
| Novartis Investigative Site | Uijeongbu-Si, Gyeonggi-do, Korea, Republic of, 480-717 Recruiting |
| Novartis Investigative Site | Daejeon, Korea, Republic of, 301-804 Recruiting |
| Novartis Investigative Site | Incheon, Korea, Republic of, 403-010 Recruiting |
| Novartis Investigative Site | Seoul, Korea, Republic of, 137-701 Recruiting |
| Novartis Investigative Site | Seoul, Korea, Republic of, 130-709 Recruiting |
| Novartis Investigative Site | Seoul, Korea, Republic of, 150-713 Recruiting |
| Novartis Investigative Site | Jelgava, LV, Latvia, 3001 Recruiting |
| Novartis Investigative Site | Liepaja, LV, Latvia, 3401 Recruiting |
| Novartis Investigative Site | Ogre, LV, Latvia, 5001 Recruiting |
| Novartis Investigative Site | Riga, LV, Latvia, 1011 Recruiting |
| Novartis Investigative Site | Riga, LV, Latvia, 1002 Recruiting |
| Novartis Investigative Site | Talsi, LV, Latvia, 3201 Recruiting |
| Novartis Investigative Site | Daugavplis, Latvia, LV-5417 Recruiting |
| Novartis Investigative Site | Riga, Latvia, 1002 Recruiting |
| Novartis Investigative Site | Valmiera, Latvia, 4201 Not yet recruiting |
| Novartis Investigative Site | Vilnius, LT, Lithuania Recruiting |
| Novartis Investigative Site | Jonava, Lithuania, 55268 Recruiting |
| Novartis Investigative Site | Kaunas, Lithuania, 48259 Recruiting |
| Novartis Investigative Site | Kaunas, Lithuania, 51270 Recruiting |
| Novartis Investigative Site | Kaunas, Lithuania, 50009 Recruiting |
| Novartis Investigative Site | Vilnius, Lithuania, LT-10207 Withdrawn |
| Novartis Investigative Site | Vilnius, Lithuania, LT-08661 Recruiting |
| Novartis Investigative Site | Kota Bahru, Kelantan, Malaysia, 16150 Recruiting |
| Novartis Investigative Site | Kuala Lumpur, Malaysia, 59100 Recruiting |
| Novartis Investigative Site | Kuala Lumpur, Malaysia, 56000 Recruiting |
| Novartis Investigative Site | Ciudad De Mexico, Distrito Federal, Mexico, 11850 Recruiting |
| Novartis Investigative Site | México, Distrito Federal, Mexico, 14000 Recruiting |
| Novartis Investigative Site | México, Distrito Federal, Mexico, 03800 Recruiting |
| Novartis Investigative Site | México D.F, Distrito Federal, Mexico, 03100 Recruiting |
| Novartis Investigative Site | Pachuca, Hidalgo, Mexico, 42086 Recruiting |
| Novartis Investigative Site | Cuautla, Morelos, Mexico, 62746 Recruiting |
| Novartis Investigative Site | Cuernavaca, Morelos, Mexico, 62250 Recruiting |
| Novartis Investigative Site | Aguascalientes, Mexico, 20230 Recruiting |
| Novartis Investigative Site | Durango, Mexico, 34000 Recruiting |
| Novartis Investigative Site | Querétaro, Mexico, 76000 Recruiting |
| Novartis Investigative Site | Fetsund, Norway, 1900 Recruiting |
| Novartis Investigative Site | Hønefoss, Norway, 3515 Recruiting |
| Novartis Investigative Site | Oslo, Norway, 0424 Recruiting |
| Novartis Investigative Site | Skedsmokorset, Norway, 2020 Recruiting |
| Novartis Investigative Site | Panama City, Panamá, Panama Recruiting |
| Novartis Investigative Site | Panama City, Panamá, Panama, 0834-01862 Recruiting |
| Novartis Investigative Site | Trujillo, La Libertad, Peru Recruiting |
| Novartis Investigative Site | Cercado de Lima, Lima, Peru, 01 Recruiting |
| Novartis Investigative Site | Chorrillos, Lima, Peru, 09 Recruiting |
| Novartis Investigative Site | Magdalena, Lima, Peru, 17 Recruiting |
| Novartis Investigative Site | San Isidro, Lima, Peru, 27 Recruiting |
| Novartis Investigative Site | Santiago de Surco, Lima, Peru, 33 Not yet recruiting |
| Novartis Investigative Site | Arequipa, Peru Recruiting |
| Novartis Investigative Site | Marikina, Metro Manila, Philippines, 1810 Recruiting |
| Novartis Investigative Site | Quezon City, Metro Manila, Philippines, 1109 Recruiting |
| Novartis Investigative Site | Marikina City, Philippines Recruiting |
| Novartis Investigative Site | Metro Manila, Philippines, 1500 Recruiting |
| Novartis Investigative Site | Pasay City, Philippines, 1300 Recruiting |
| Novartis Investigative Site | Pasig City, Philippines, 1600 Recruiting |
| Novartis Investigative Site | Kutno, Poland, 99-300 Recruiting |
| Novartis Investigative Site | Poznan, Poland, 60-823 Recruiting |
| Novartis Investigative Site | Poznan, Poland, 61-655 Recruiting |
| Novartis Investigative Site | Poznan, Poland, 61-251 Not yet recruiting |
| Novartis Investigative Site | Wroclaw, Poland, 51-162 Not yet recruiting |
| Novartis Investigative Site | Zabrze, Poland, 41-800 Recruiting |
| Novartis Investigative Site | Oradea, Jud. Bihor, Romania, 410619 Recruiting |
| Novartis Investigative Site | Oradea, Jud. Bihor, Romania, 410032 Recruiting |
| Novartis Investigative Site | Ploiesti, Jud. Prahova, Romania, 100097 Recruiting |
| Novartis Investigative Site | Bucharest, Romania, 020475 Recruiting |
| Novartis Investigative Site | Bucharest, Romania, 020045 Recruiting |
| Novartis Investigative Site | Bucuresti, Romania Recruiting |
| Novartis Investigative Site | Timisoara, Romania Not yet recruiting |
| Novartis Investigative Site | Krasnodar, Russian Federation, 350063 Withdrawn |
| Novartis Investigative Site | Moscow, Russian Federation, 101953 Recruiting |
| Novartis Investigative Site | N.Novgorod, Russian Federation, 603126 Recruiting |
| Novartis Investigative Site | Penza, Russian Federation, 440026 Recruiting |
| Novartis Investigative Site | Petrozavodsk, Russian Federation, 185019 Recruiting |
| Novartis Investigative Site | Ryazan, Russian Federation, 390026 Recruiting |
| Novartis Investigative Site | Saint-Petersburg, Russian Federation, 198260 Recruiting |
| Novartis Investigative Site | Saint-Petersburg, Russian Federation, 198013 Recruiting |
| Novartis Investigative Site | Saratov, Russian Federation, 410012 Recruiting |
| Novartis Investigative Site | Smolensk, Russian Federation, 214019 Recruiting |
| Novartis Investigative Site | St-Petersburg, Russian Federation, 194358 Recruiting |
| Novartis Investigative Site | St.- Petersburg, Russian Federation, 199034 Recruiting |
| Novartis Investigative Site | Bratislava, Slovak Republic, Slovakia, 85101 Recruiting |
| Novartis Investigative Site | Kosice, Slovak Republic, Slovakia, 04001 Recruiting |
| Novartis Investigative Site | Lucenec, Slovak Republic, Slovakia, 98401 Recruiting |
| Novartis Investigative Site | Namestovo, Slovak Republic, Slovakia, 02901 Recruiting |
| Novartis Investigative Site | Roznava, Slovak Republic, Slovakia, 04801 Recruiting |
| Novartis Investigative Site | Sala, Slovak Republic, Slovakia, 92701 Recruiting |
| Novartis Investigative Site | Trebisov, Slovak Republic, Slovakia, 075 01 Recruiting |
| Novartis Investigative Site | Zilina, Slovak Republic, Slovakia, 010 01 Not yet recruiting |
| Novartis Investigative Site | Banska Bystrica, Slovakia, 974 01 Not yet recruiting |
| Novartis Investigative Site | Kosice, Slovakia, 040 01 Recruiting |
| Novartis Investigative Site | Kosice, Slovakia, 040 01 Not yet recruiting |
| Novartis Investigative Site | Kosice, Slovakia, 040 22 Recruiting |
| Novartis Investigative Site | Levice, Slovakia, 934 01 Recruiting |
| Novartis Investigative Site | Nové Zámky, Slovakia, 940 01 Recruiting |
| Novartis Investigative Site | Presov, Slovakia, 080 01 Recruiting |
| Novartis Investigative Site | Sabinov, Slovakia, 08301 Not yet recruiting |
| Novartis Investigative Site | Sered, Slovakia, 92601 Recruiting |
| Novartis Investigative Site | Sturovo, Slovakia, 94301 Not yet recruiting |
| Novartis Investigative Site | Trnava, Slovakia, 917 01 Not yet recruiting |
| Novartis Investigative Site | Zilina, Slovakia, 012 07 Recruiting |
| Novartis Investigative Site | Alberton, South Africa, 1449 Recruiting |
| Novartis Investigative Site | Cape Town, South Africa, 7925 Recruiting |
| Novartis Investigative Site | Cape Town, South Africa Withdrawn |
| Novartis Investigative Site | Durban, South Africa, 4126 Recruiting |
| Novartis Investigative Site | Durban, South Africa, 4030 Recruiting |
| Novartis Investigative Site | Gauteng, South Africa Recruiting |
| Novartis Investigative Site | Johannesburg, South Africa, 1820 Recruiting |
| Novartis Investigative Site | Kempton Park, South Africa, 1620 Withdrawn |
| Novartis Investigative Site | Pretoria, South Africa, 0184 Not yet recruiting |
| Novartis Investigative Site | Pretoria, South Africa, 1022 Not yet recruiting |
| Novartis Investigative Site | Pretoria, South Africa, 0002 Not yet recruiting |
| Novartis Investigative Site | Yungkang, Tainan, Taiwan, 710 Withdrawn |
| Novartis Investigative Site | Changhua, Taiwan, 500 Withdrawn |
| Novartis Investigative Site | Chia-Yi, Taiwan, 600 Not yet recruiting |
| Novartis Investigative Site | Hsintien, Taiwan, 231 Recruiting |
| Novartis Investigative Site | Lin-Ko, Taiwan, 33305 Recruiting |
| Novartis Investigative Site | Taichung, Taiwan, 40705 Recruiting |
| Novartis Investigative Site | Taipei, Taiwan, 114 Recruiting |
| Novartis Investigative Site | Adana, Turkey, 01330 Recruiting |
| Novartis Investigative Site | Antalya, Turkey, 07070 Not yet recruiting |
| Novartis Investigative Site | Diskapi / Ankara, Turkey, 06770 Recruiting |
| Novartis Investigative Site | Istanbul, Turkey, 34093 Not yet recruiting |
| Novartis Investigative Site | Istanbul, Turkey, 34304 Not yet recruiting |
| Novartis Investigative Site | Istanbul, Turkey, 34093 Recruiting |
| Novartis Investigative Site | Izmir, Turkey, 35040 Recruiting |
| Novartis Investigative Site | Izmir, Turkey, 35340 Recruiting |
| Novartis Investigative Site | Kahramanmaras, Turkey, 46100 Recruiting |
| Novartis Investigative Site | Karsiyaka / Izmir, Turkey, 35590 Not yet recruiting |
| Novartis Investigative Site | Kinikli / Denizli, Turkey, 20070 Recruiting |
| Novartis Investigative Site | Kocaeli, Turkey, 41380 Not yet recruiting |
| Novartis Investigative Site | Manisa, Turkey, 45040 Not yet recruiting |
| Novartis Investigative Site | Yenisehir / Izmir, Turkey Not yet recruiting |