Study Comparing AEZS-108/ZoptEC (Zoptarelin Doxorubicin in Endometrial Cancer) to Doxorubicin as a Second Line Therapy of Endometrial Cancer
Overview[ - collapse ][ - ]
| Purpose | Open-label, randomized, active-controlled, two-arm Phase III study to compare the efficacy and safety of AEZS-108 and doxorubicin. The study will include about 500 patients with endometrial cancer resistant to platinum/taxane-based chemotherapy. |
|---|---|
| Condition | Endometrial Cancer |
| Intervention | Drug: AEZS-108 / zoptarelin doxorubicin Drug: doxorubicin |
| Phase | Phase 3 |
| Sponsor | AEterna Zentaris |
| Responsible Party | AEterna Zentaris |
| ClinicalTrials.gov Identifier | NCT01767155 |
| First Received | January 9, 2013 |
| Last Updated | April 24, 2014 |
| Last verified | September 2013 |
Tracking Information[ + expand ][ + ]
| First Received Date | January 9, 2013 |
|---|---|
| Last Updated Date | April 24, 2014 |
| Start Date | April 2013 |
| Estimated Primary Completion Date | January 2016 |
| Current Primary Outcome Measures | Compare the overall survival (OS) of patients treated with AEZS-108 to the OS of patients treated with doxorubicin. [Time Frame: 3 years] [Designated as safety issue: No] |
| Current Secondary Outcome Measures |
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Descriptive Information[ + expand ][ + ]
| Brief Title | Study Comparing AEZS-108/ZoptEC (Zoptarelin Doxorubicin in Endometrial Cancer) to Doxorubicin as a Second Line Therapy of Endometrial Cancer |
|---|---|
| Official Title | Randomized Controlled Study Comparing AEZS-108 With Doxorubicin as Second Line Therapy for Locally Advanced, Recurrent or Metastatic Endometrial Cancer. |
| Brief Summary | Open-label, randomized, active-controlled, two-arm Phase III study to compare the efficacy and safety of AEZS-108 and doxorubicin. The study will include about 500 patients with endometrial cancer resistant to platinum/taxane-based chemotherapy. |
| Detailed Description | Not Provided |
| Study Type | Interventional |
| Study Phase | Phase 3 |
| Study Design | Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment |
| Condition | Endometrial Cancer |
| Intervention | Drug: AEZS-108 / zoptarelin doxorubicin 267 mg/m2 by 2-hour intravenous infusion, on Day 1 of 21-day (3-week) cycles for a maximun of 9 cycles Drug: doxorubicin 60 mg/m2 by intravenous bolus injection or 1-hour intravenous infusion, on Day 1 of 21-day (3-week) cycles |
| Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
| Recruitment Status | Recruiting |
|---|---|
| Estimated Enrollment | 500 |
| Estimated Completion Date | January 2016 |
| Estimated Primary Completion Date | December 2015 |
| Eligibility Criteria | Inclusion Criteria: 1. Women ≥ 18 years of age 2. Histologically confirmed endometrial cancer 3. Advanced (FIGO stage III or IV), recurrent or metastatic disease. 4. Measurable or non-measurable disease that has progressed since last treatment. 5. Patients who have progressed after prior first line treatment with platinum/taxane based chemotherapy for advanced, recurrent or metastatic endometrial cancer. 6. Availability of fresh or archival FFPE tumor specimens for analysis of LHRH receptor expression. Exclusion Criteria: 1. ECOG performance status > 2. 2. Inadequate hematologic, hepatic or renal function 3. Red blood cell transfusion within 2 weeks prior to anticipated start of study treatment. 4. History of myocardial infarction, unstable angina, or uncontrolled arrhythmia within the past 6 months. 5. Impaired cardiac function defined as left ventricular ejection fraction (LVEF) < 50 % as measured by MUGA or ECHO. 6. Planned concomitant use of potentially cardiotoxic medication 7. Chemo-, immune-, hormone-, or radiotherapy (including pre- or post-operative brachytherapy) within 4 weeks prior to randomization. 8. Previous anthracycline-based chemotherapy. 9. Anticipated ongoing concomitant anticancer therapy during the study. 10. History of serious co-morbidity or uncontrolled illness that would preclude study therapy, such as active tuberculosis or any other active infection. 11. Brain metastasis, leptomeningeal disease. 12. Pregnant or lactating female or female of child-bearing potential not employing adequate contraception. 13. Receipt of 2 or more prior chemotherapy regimens for advanced, recurrent, or metastatic endometrial cancer. 14. Prior treatment with AEZS-108. 15. Use of LHRH agonist or antagonist treatment within 6 months prior to randomization. 16. Malignancy within last 5 years except non-melanoma skin cancer. 17. Any concomitant disease or condition which would interfere with the subjects' proper completion of the protocol assignment. 18. Concomitant or recent treatment with other investigational drug (within 8 weeks or 5 elimination half life times prior to anticipated start of study treatment). 19. Lack of ability or willingness to give informed consent. 20. Anticipated non-availability for study visits/procedures. |
| Gender | Female |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Contact: Ines Altemose 908-626-5510 IAltemose@aezsinc.com |
| Location Countries | United States, Austria, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Czech Republic, Ireland, Israel, Italy, Netherlands, Norway, Poland, Romania, Russian Federation, Spain, Ukraine, United Kingdom |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01767155 |
|---|---|
| Other Study ID Numbers | AEZS -108-050 |
| Has Data Monitoring Committee | Yes |
| Information Provided By | AEterna Zentaris |
| Study Sponsor | AEterna Zentaris |
| Collaborators | Not Provided |
| Investigators | Principal Investigator: David Scott Miller, MD University of Texas Southwestern Medical Center, Dallas, USAPrincipal Investigator: Hani Gabra, MD Imperial College London Hammersmith Campus, London, UK |
| Verification Date | September 2013 |
Locations[ + expand ][ + ]
| St. Joseph's Hospital and Medical Center | Phoenix, Arizona, United States, 85013 Contact: Kelli Williamson | 602-406-6689Principal Investigator: Lyndsay Willmott, Dr Recruiting |
|---|---|
| University of California, Irvine - Medical Center | Orange, California, United States, 92868-3200 Contact: Samantha Reiter | 714-456-6846Principal Investigator: Krishnansu S Tewari, MD Recruiting |
| University of Colorado | Aurora, Colorado, United States, 80045 Contact: Rebecca Kissane | 720-848-7202Principal Investigator: Monique A. Spillman, MD Recruiting |
| Hartford Hospital | Hartford, Connecticut, United States, 06106 Contact: Kathy Alexander | 860-545-3553Principal Investigator: Amy Brown, Dr Recruiting |
| The Hospital of Central Connecticut | New Britain, Connecticut, United States, 06050 Contact: Siobhan Reilly | 860-224-59006718Principal Investigator: James Hoffman, MD Recruiting |
| Moffitt Cancer Center | Tampa, Florida, United States, 33612 Contact: Jennifer Tiemann | 813-745-7272Principal Investigator: Robert Wenham, MD Recruiting |
| Northside Hospital | Atlanta, Georgia, United States, 30342 Contact: Qun Zeng | 404-845-5053Principal Investigator: Benedict Benigno, MD Recruiting |
| Northwestern University | Chicago, Illinois, United States, 60611 Contact: Rachel Bers, CCRP | 312-472-5726Principal Investigator: Nikki Neubauer, MD Recruiting |
| University of Iowa Hospitals and Clinics | Iowa City, Iowa, United States, 52242 Contact: Sharon Stockman | 319-356-2015Principal Investigator: David Bender, MD Recruiting |
| Women's Cancer Center | Covington, Louisiana, United States, 70433 Contact: Cheryl Thomas | 985-892-2252Principal Investigator: Patricia Braly, MD Recruiting |
| University of Maryland Greenebaum Cancer Center | Baltimore, Maryland, United States, 21201 Contact: Michelle Besche | 410-328-8610Principal Investigator: Sarah Temkin, MD Recruiting |
| Massachusetts General Hospital Cancer Center | Boston, Massachusetts, United States, 02114 Contact: Don Dizon | 617-724-4800Principal Investigator: Don Dizon, Dr Recruiting |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States, 02215 Contact: Siobhan Collins | 617-632-2580Principal Investigator: Don Dizon, Dr. Recruiting |
| Washington University School of Medecine | St Louis, Missouri, United States, 63110 Contact: Lynne Lippmann | 314-362-1760Principal Investigator: Premal Thaker, MD Recruiting |
| Memorial Sloan-Kettering Cancer Institute | New York, New York, United States, 10065 Contact: Jason Konner, MD | 646-888-4219Principal Investigator: Jason Konnor, MD Recruiting |
| Hope Women's Cancer Centers / Mission Hospital, Inc. | Asheville, North Carolina, United States, 28806 Contact: Laura Murphy | 828-670-8403Principal Investigator: Timothy Vanderkwaak, MD Recruiting |
| Levine Cancer Institute | Charlotte, North Carolina, United States, 28204 Contact: Sarah Norek | 980-442-2300Principal Investigator: David L. Tait, MD Recruiting |
| Roger Maris Cancer Center | Fargo, North Dakota, United States, 58122 Contact: Collette Springman | 605-328-1384Principal Investigator: Maria Bell, MD Recruiting |
| Ohio State University Wexner Medical Center | Columbus, Ohio, United States, 43210 Contact: Leena Hiremath | 614-366-9088Principal Investigator: David O'Malley, MD Recruiting |
| Peggy and Charles Oklahoma Cancer Center | Oklahoma City, Oklahoma, United States, 73104 Contact: Michelle Stephens | 405-271-8777Principal Investigator: Scott McMeekin, MD Recruiting |
| Sanford Research/USD | Sioux Falls, South Dakota, United States, 57104 Contact: Collette Springman | 605-328-1384Principal Investigator: Maria Bell, MD Recruiting |
| University of Texas Southwestern Medical Center | Dallas, Texas, United States, 75390-9179 Contact: Isabel Villalobos | 214-648-7010Principal Investigator: David Scott Miller, MD Recruiting |
| University of Virginia | Charlottesville, Virginia, United States, 22908 Contact: Tomothy Howland | 434-243-0032Principal Investigator: Linda Duska, MD Recruiting |
| Inova Fairfax Hospitals | Falls Church, Virginia, United States, 22024 Contact: Kelly Jeffords | 571-308-1830344Principal Investigator: Larry Maxwell, MD Recruiting |
| Henrico Doctor's Hospital | Richmond, Virginia, United States, 23229 Contact: Deidre Belcher | 804-289-4672Principal Investigator: Cecelia Boardman, MD Recruiting |
| Medizinische Universität Innsbruck | Innsbruck, Austria, 6020 Contact: Alain-Gustave Zeimet | +43 (0)50504-24155Principal Investigator: Alain-Gustave Zeimet, Prof.Dr Recruiting |
| Medizinische Universität Innsbruck | Innsbruck, Austria, 6020 Contact: Alain-Gustave Zeimet | +43 (0)50504-24155Principal Investigator: Alain-Gustave Zeimet, Prof. Dr. Recruiting |
| Minsk City Clinical Oncologic Dispensary | Minsk, Belarus Contact: Yauheni Baranau | +375 29 627 2018Principal Investigator: Yauheni Baranau, Dr Recruiting |
| Alexandrov National Cancer centre of Belarus | Minsk, Belarus, 223040 Contact: Ivan Zhuravkin | +375 17 265 3781Principal Investigator: Edvard Zhavrid, Dr Recruiting |
| Mogilev Regional Clinical Oncologic Dispensary | Mogilev, Belarus, 212018 Contact: Elena Ezubchyk | +375 29 664 6877Principal Investigator: Elena Ezubchyk, Dr Recruiting |
| Vitebsk Regional Clinical Oncologic Dispensary | Vitebsk, Belarus, 210603 Contact: Natalia Matora | +375 21 257 2179Principal Investigator: Valiantina Kliuchanok, Dr Recruiting |
| Institut Jules Bordet | Brussels, Belgium, 1000 Contact: Joseph Kerger | +32 2 541 73 96Principal Investigator: Joseph Kerger, Dr Recruiting |
| UZ Leuven - Campus Gasthuisberg | Leuven, Belgium Contact: Tine Op de beeck | +32 16 34 29 23Principal Investigator: Ignace Vergote, Prof. Recruiting |
| Hospital Centre Liege University_CHU Sart Tilman | Liege, Belgium, 4000 Contact: Frederic Kridelka | +32 43 67 82 50Principal Investigator: Frederic Kridelka, Prof. Dr. Recruiting |
| CHWAPI | Tournai, Belgium, 7500 Contact: Olivia Ponchau | +32 69 88 50 30Principal Investigator: Catherine Dopchie, Dr Recruiting |
| Clinical Center Banja Luka, Oncology Clinic | Banja Luka, Bosnia and Herzegovina, 78000 Contact: Zivko Vranjes, Dr | +387 65 880 811Principal Investigator: Zivko Vranjes, Dr Recruiting |
| University Clinical Hospital Mostar, Oncology clinic | Mostar, Bosnia and Herzegovina, 88000 Contact: . Inga Marijanovic, Dr | +387 61 194 686Principal Investigator: Inga Marijanovic, Dr Recruiting |
| Clinical Centre University of Sarajevo | Sarajevo, Bosnia and Herzegovina, 71000 Contact: Anes Pasic | 00 387 217 499 / 00 387 33 298Principal Investigator: Anes Pasic, MD Recruiting |
| Specialized Hospital for Active Treatment in Obstetrics and Gynecology | Pleven, Bulgaria Contact: Grigor Gortchev | +359 887 511 531Principal Investigator: Grigor Gortchev, Prof. Recruiting |
| Cross Cancer Institute | Edmonton, Alberta, Canada, T6G 1Z2 Contact: Wanda Gaudon | (780) 577-8029Principal Investigator: Katia Tonkin, Dr Recruiting |
| Princess Margaret Cancer Center | Toronto, Ontario, Canada, M5G 2M9 Contact: Judy Quintos | 416-946-45015322Principal Investigator: Amit M Oza, Dr Recruiting |
| Hopital Notre Dame - CHUM | Montreal, Quebec, Canada, H2L 4M1 Contact: Bonny Choy | 514-890-800024672Principal Investigator: Diane Provencher, Dr Recruiting |
| McGill University | Montreal, Quebec, Canada, H2W 1S6 Contact: Penny Chipman | 514-398-1444Principal Investigator: Suzy Lau, Dr Recruiting |
| Royal Victoria Hospital | Montreal, Quebec, Canada, H3A 1A1 Contact: Natacha Albarracin | (514) 934-193431975Principal Investigator: Lucy Gilbert, Dr Recruiting |
| Hotel Dieu de Quebec- CHUQ | Quebec, Canada, G1R 2J6 Contact: Theresa Jones | 418 691-5181Principal Investigator: Vincent Castonguay, Dr Recruiting |
| Masarykův onkologický ústav | Brno, Czech Republic, 65653 Contact: Jana Haičmanová | 00420-543135222Principal Investigator: Josef Chovanec, Dr Recruiting |
| Fakultní nemocnice Olomouc | Olomouc, Czech Republic, 77520 Contact: Magda Šimková | 420588442522Principal Investigator: Bohuslav Melichar, Dr Recruiting |
| Všeobecná fakultní nemocnice v Praze | Praha, Czech Republic, 12851 Contact: David Cibula | 00420 224 967 481Principal Investigator: David Cibula, Prof. Recruiting |
| St James's Hospital | Dublin, Ireland, 8 Contact: Dearbhaile O'Donnell | 00 353 1 410 3973Principal Investigator: Dearbhaile O'Donnell, Dr Recruiting |
| Mater Private Hospital | Dublin, Ireland, 7 Contact: Martina Smith | 00 353 1 8034838Principal Investigator: David Gallagher, Dr Recruiting |
| Mater Misericordiae University Hospital | Dublin, Ireland, 7 Contact: Martina Smith | 00 353 1 8034838Principal Investigator: David Gallagher, Dr Recruiting |
| University Hospital Galway | Galway, Ireland Contact: Maccon Keane | 00 353 91 544735Principal Investigator: Maccon Keane, Dr. Recruiting |
| Waterford Regional Hospital | Waterford, Ireland Contact: Elaine S Shanahan | 00 353 51 848934Principal Investigator: Paula Calvert, Dr Recruiting |
| Barzilai Medical Center | Ashkelon, Israel, 78278 Contact: Frida Barak, Dr | 08-6745378Principal Investigator: Frida Barak, Dr Recruiting |
| Rambam Health Care Campus | Haifa, Israel, 31096 Contact: Amnon Amit, Dr | 04-8543872Principal Investigator: Amnon Amit, Dr Recruiting |
| Hadassah Hospital | Jerusalem, Israel, 91120 Contact: David Edelmann, Dr | 02-6777365Principal Investigator: David Eldelmann, Dr Recruiting |
| Davidoff Center, Rabin Medical Center | Petah-Tikva, Israel, 49100 Contact: Claude Koren, Dr | 03-9378002Principal Investigator: Claude Koren, Dr Recruiting |
| Oncology Institute Kaplan | Rehovot, Israel, 76100 Contact: Adelya Yachnin, Dr | 08-9441975Principal Investigator: Adelya Yachnin, Dr Recruiting |
| Tel Aviv Sourasky Medical Center | Tel Aviv, Israel, 64239 Contact: Diana Matceyevsky, Dr | 03-6973997Principal Investigator: Diana Matceyevsky, Dr Recruiting |
| Chaim Sheba Medical Center | Tel Hashomer, Israel, 52661 Contact: Tamar Perri, Dr | 972-52-6666444Principal Investigator: Tamar Perri, Dr Recruiting |
| Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari | Bari, Italy, 70124 Contact: Luigi Selvaggi | +39 080 5478986Principal Investigator: Luigi Selvaggi, Dr. Recruiting |
| Azienda Ospedaliero-Universitaria di Modena | Modena, Italy, 41124 Contact: Roberto Sabbatini | +39 059 4222648Principal Investigator: Roberto Sabbatini, Dr Recruiting |
| Istituto Nazionale Tumori IRCCS | Napoli, Italy, 80131 Contact: Carmela Pisano | +39 081 5903637Principal Investigator: Carmela Pisano, Dr Recruiting |
| Istituto Oncologico Veneto, IRCCS | Padova, Italy, 35128 Contact: Pier Franco Conte | +39 049 8215931Principal Investigator: Pier Franco Conte, Prof. Recruiting |
| Azienda Ospedaliera Ospedali Riuniti Marche Nord | Pesaro, Italy, 61122 Contact: Giammaria Fiorentini | +39 0721 364124Principal Investigator: Giammaria Fiorentini, Dr Recruiting |
| Policlinico A. Gemelli | Rome, Italy, 00168 Contact: Giovanni Scambia | +39 06 30156279Principal Investigator: Giovanni Scambia, Dr Recruiting |
| Academic Medical Center | Amsterdam, Netherlands, 1105 Contact: Lyda ter Hofstede | trialmedonc@amc.uva.nlPrincipal Investigator: Anne Marie Westermann, Dr. Recruiting |
| Maastricht University Medical Center (UMC) | HX Maastricht, Netherlands, 6229 Contact: Roy Lalisang | +31 43 3876007Principal Investigator: Roy Lalisang, Dr. Recruiting |
| The Norwegian Radium Hospital | Oslo, Norway, 0310 Contact: Gunnar Kristensen | +47 22934000Principal Investigator: Gunnar Kristensen, Dr. Recruiting |
| Helse Stavanger HF, Stavanger Universitetssjukhus | Stavanger, Norway, NO-4068 Contact: Bent Fiane | 004751519470Principal Investigator: Bent Fiane, Dr. Recruiting |
| Bialostockie Centrum Onkologii | Bialystok, Poland, 15-027 Contact: Beata Mackowiak-Matejczyk | +48 85 664 67 32.Principal Investigator: Beata Mackowiak-Matejczyk, Dr Recruiting |
| I Klinika Ginekologii Onkologicznej i Ginekologii | Lublin, Poland, 20-081 Contact: Jan Kotarski, Prof. | +48815327847Principal Investigator: Jan Kotarski, Prof. Recruiting |
| Wojewodzki Szpital Specjalistyczny | Olsztyn, Poland, 10-561 Contact: Malgorzata Sikorska | +48895386563Principal Investigator: Malgorzata Sikorska, Dr Recruiting |
| NZOZ Magodent, Szpital Onkologiczny | Warszawa, Poland, 03-291 Contact: Malgorzata Stelmaszuk | +48 22 326 98 66Principal Investigator: Malgorzata Stelmaszuk Recruiting |
| Centrum Terapii Współczesnej ul. | Łódź, Poland, 90-242 Contact: Malgorzata Ułańska | +48 42 230 06 09Principal Investigator: Malgorzata Ułańska, Dr Recruiting |
| Oncolab | Craiova, Dolj county, Romania, 200385 Contact: Denis Diaconescu | 0040 251 531 088Principal Investigator: Michael Schenker, Dr Recruiting |
| Spitalul Clinic Judetean Mures | Targu Mures, Mures county, Romania, 540072 Contact: Toganel Cornelia | 0040 265 210 947Principal Investigator: Toganel Cornelia, Dr Recruiting |
| Oncology Institute "Prof. Dr. I. Chiricuta" | Cluj Npaoca, Romania, 400015 Contact: Calin Cainap | +40 264 598 361Principal Investigator: Calin Ioan Cainap, Dr Recruiting |
| Spitalul Clinic Judetean de Urgenta "Sf. Ioan cel Nou" | Suceava, Romania, 720237 Contact: Toderas Mihai | 0040230222098Principal Investigator: Doina Elena Ganea, Dr Recruiting |
| Oncomed | Timisoara, Romania, 300239 Contact: Daniela Elvira Sirbu, Dr | 0040 256 495 403Principal Investigator: Daniela Elvira Sirbu, Dr Recruiting |
| FGBU "RONC n.a. N.N. Blokhin" | Moscow, Russian Federation, 115478 Contact: Dmitry Komov | +7 499 324 7248Principal Investigator: Dmitry Komov, Prof. Recruiting |
| Nizhny Novgorod Regional Oncology Dispensary | Nizhny Novgorod, Russian Federation, 603081 Contact: Vitaliy Mihaylovich Terekhov | 007 831 4643777Principal Investigator: Marina Matrosova, MD Recruiting |
| FGBU "NIIO n.a. N.N. Petrov" | Saint-Petersburg, Russian Federation Contact: Roman Donkikh | - + 7 (812) 439-95-15Principal Investigator: Roman Donkikh, Dr Recruiting |
| Budget Institution of Health / Leningrad Regional Oncological Dispensary | St. Petersburg, Russian Federation, 191014 Contact: Tatiana Potetyurina | +7 921 940-15-43Principal Investigator: Olga Mikheeva, MD Recruiting |
| Saint-Petersburg State Budgetary Institution Healthcare "City Clinical Oncology Center" | St. Petersburg, Russian Federation, 198255 Contact: Georgy Manikhas | +7 812 7566368Principal Investigator: Alla Lisyanskaya, Dr Recruiting |
| Republican Clinical Oncology Dispensary | Ufa, Russian Federation, 450071 Contact: Irina Rakhmatullina | +7 917 7791312Principal Investigator: Irina Rakhmatullina, MD, PhD Recruiting |
| Volgograd Regional Oncology Dispensary #3 | Volzhsky, Russian Federation Contact: Ksenia Babina | - +7 8443 310663Principal Investigator: Ksenia Babina, Dr Recruiting |
| Hospital Vall d´Hebron | Barcelona, Spain Contact: Ana Oaknin | +34. 93.274.60.85Principal Investigator: Ana Oaknin, Dr Recruiting |
| Hospital Universitario 12 de Octubre | Madrid, Spain, 28045 Contact: Jesús Jiménez | 0034 913908376Principal Investigator: Jesús Jiménez, Dr Recruiting |
| Ramon Y Cajal Hospital | Madrid, Spain, 28034 Contact: Luis Barba | 0034913368263Principal Investigator: Eva Guerra, Dr. Recruiting |
| Hospital Clínico San Carlos | Madrid, Spain, 28040 Contact: Antonio Casado | +34 91 330 30 007551/7549Principal Investigator: Antonio Casado, Dr. Recruiting |
| Instituto Valenciano de Oncologia | Valencia, Spain, 46009 Contact: Pedro Mallol | 96 110 46 06Principal Investigator: Ignacio Romero, Dr. Recruiting |
| Zina Memorial Cancer Hospital (LISSOD) | Plyuty, Kiev region, Ukraine, 08720 Contact: Alla Lychko | 00380445209401Principal Investigator: Alla Vinnytska, Dr Recruiting |
| Municipal institution "Dnipropetrovsk City Multidisciplinary Clinical Hospital No. 4" | Dnepropetrovsk, Ukraine, 49102 Contact: Illiya Balakin | 00380567417418Principal Investigator: Igor Bondarenko Recruiting |
| CCMP I Donetsk Regional Anticancer Center | Donetsk, Ukraine, 83092 Contact: Pavlo Lyfar | 00380622239503Principal Investigator: Natalia Lisovska, Dr Recruiting |
| Public health enterprise "Kharkov regional Clinical Oncological Center" | Kharkov, Ukraine, 61070 Contact: Vladislav Bakhtalovskiy | +380573150124Principal Investigator: Yuri Vinnyk, Dr. Recruiting |
| Kiev City Clinical Oncology Center | Kiev, Ukraine, 03115 Contact: Olena Manzhura | 00380444508239Principal Investigator: Olena Manzhura, MD Recruiting |
| Zakarpatskyi Regional Clinical Oncology Dispensary | Uzhgorod, Ukraine, 88014 Contact: Taras Shlakhta | +380312615613Principal Investigator: Andriy Rusyn, Dr Recruiting |
| Vinnitsa Regional Clinical Oncology Dispensary | Vinnitsa, Ukraine, 21029 Contact: Oksana Mashevska | 00380432511434Principal Investigator: Serhiy Odarchenko, Dr Recruiting |
| The Royal Marsden Hospital NHS Foundation Trust | Sutton, Surrey, United Kingdom, SM2 5PT Contact: Susana Banerjee | 00 44 208 661 3539Principal Investigator: Susana Banerjee, Dr Recruiting |
| The Clatterbridge Cancer Centre NHS Foundation Trust | Bebington, Wirral, United Kingdom, CH63 4JY Contact: Laurie Lomax | +44 151 482 78044926Principal Investigator: John Green, Dr Recruiting |
| University Hospitals Coventry and Warwickshire NHS Trust | Coventry, United Kingdom, CV2 2DX Contact: Tracey Preston | +44 2476 96747627476Principal Investigator: Christopher Poole, Dr. Recruiting |
| Imperial college Healthcare NHS Trust | London, United Kingdom Contact: Daisy Shinmar | 00 44 208 383 6457Principal Investigator: Hani Gabra, Prof. Recruiting |
| Nottingham City Hospital NHS Trust | Nottingham, United Kingdom, NG5 1PB Contact: Stephan Chan | 0044 115 969 116957298Principal Investigator: Stephan Chan, Dr Recruiting |