A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma
Overview[ - collapse ][ - ]
| Purpose | The purpose of this study is to evaluate if ibrutinib administered in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) improves the clinical outcome in newly diagnosed patients with non-germinal center B-cell subtype (GCB) of diffuse large B-cell lymphoma (DLBCL). |
|---|---|
| Condition | Lymphoma |
| Intervention | Drug: Ibrutinib Drug: Placebo Drug: Rituximab Drug: Cyclophosphamide Drug: Doxorubicin Drug: Vincristine Drug: Prednisone (or equivalent) |
| Phase | Phase 3 |
| Sponsor | Janssen Research & Development, LLC |
| Responsible Party | Janssen Research & Development, LLC |
| ClinicalTrials.gov Identifier | NCT01855750 |
| First Received | May 14, 2013 |
| Last Updated | April 24, 2014 |
| Last verified | April 2014 |
Tracking Information[ + expand ][ + ]
| First Received Date | May 14, 2013 |
|---|---|
| Last Updated Date | April 24, 2014 |
| Start Date | September 2013 |
| Estimated Primary Completion Date | June 2020 |
| Current Primary Outcome Measures | Event-free survival [Time Frame: Up to disease progression, relapse from complete response, initiation of subsequent systemic antilymphoma therapy after completion of at least 6 cycles of R-CHOP therapy, or death, whichever occurs first, up to Year 7] [Designated as safety issue: No] |
| Current Secondary Outcome Measures |
|
Descriptive Information[ + expand ][ + ]
| Brief Title | A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma |
|---|---|
| Official Title | A Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma |
| Brief Summary | The purpose of this study is to evaluate if ibrutinib administered in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) improves the clinical outcome in newly diagnosed patients with non-germinal center B-cell subtype (GCB) of diffuse large B-cell lymphoma (DLBCL). |
| Detailed Description | This is a randomized (individuals assigned to study treatment by chance), double-blind (individuals and study personnel will not know the identity of study treatments), placebo (an inactive substance that is compared with a drug to test whether the drug has a real effect in a clinical trial)-controlled study to compare the efficacy and safety of ibrutinib in combination with R-CHOP versus R-CHOP alone in adult patients newly diagnosed non-GCB DLBCL. The study will include screening, active treatment, and posttreatment follow-up phases. The study will end when 50% of participants have died or the sponsor terminates the study, whichever occurs first (up to approximately 7 years). Approximately 800 participants will be randomly assigned in a 1:1 ratio to receive either placebo+R-CHOP (treatment arm A) or ibrutinib+R-CHOP (treatment arm B). All participants will receive R-CHOP as background therapy for 6 or 8 cycles (21 days per cycle) prespecified according to local practice. After 4 treatment cycles, an interim response assessment will be performed to evaluate disease progression for each participant. Participants with progressive disease or relapsed disease after complete response will be discontinued from treatment. Participants who discontinue R-CHOP without disease progression will continue study drug (placebo or ibrutinib) until 6 or 8 cycles are completed, disease progression, or unacceptable toxicity, whichever occurs first. After completion of study drug, participants will undergo assessment of tumor response based on the Revised Response Criteria for Malignant Lymphoma. Participants with documented residual disease upon completion of at least 6 cycles of R-CHOP therapy are considered eligible to initiate subsequent antilymphoma therapy. Serial pharmacokinetic samples will be collected before and after dosing, and safety will be monitored throughout the study. |
| Study Type | Interventional |
| Study Phase | Phase 3 |
| Study Design | Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment |
| Condition | Lymphoma |
| Intervention | Drug: Ibrutinib 560 mg capsules administered by mouth once daily (21-day cycles) Drug: Placebo 4 matched capsules administered by mouth once daily (21-day cycles) Drug: Rituximab 375 mg/m2 administered intravenously once on Day 1 of each cycle (21-day cycles) Drug: Cyclophosphamide 750 mg/m2 administered intravenously once on Day 1 of each cycle (21-day cycles) Drug: Doxorubicin 50 mg/m2 administered intravenously once on Day 1 of each cycle (21-day cycles) Drug: Vincristine 1.4 mg/m2 administered intravenously once on Day 1 of each cycle (21-day cycles) Drug: Prednisone (or equivalent) 100 mg capsules administered by mouth once daily on Day 1 to Day 5 of each cycle |
| Study Arm (s) |
|
Recruitment Information[ + expand ][ + ]
| Recruitment Status | Recruiting |
|---|---|
| Estimated Enrollment | 800 |
| Estimated Completion Date | June 2020 |
| Estimated Primary Completion Date | June 2018 |
| Eligibility Criteria | Inclusion Criteria: - No prior treatment for diffuse B-cell lymphoma (DLBCL) - Histologically-confirmed non-germinal center B-cell subtype DLBCL - Stage II (not candidates for local x-ray therapy), III, or IV disease by the Ann Arbor Classification - At least 1 measurable site of disease according to Revised Response Criteria for Malignant Lymphoma - Revised International Prognostic Index score of >=1 - Eastern Cooperative Oncology Group performance status grade of 0, 1, or 2 - Hematology and biochemical laboratory values within protocol-defined parameters within 14 days prior to random assignment and at baseline - Left ventricular ejection fraction within institutional normal limits, as determined by echocardiography or multiple uptake gated acquisition (MUGA) scan - Agrees to protocol-defined use of effective contraception (for women, these restrictions apply for 12 months after the last dose of rituximab or 1 month after the last dose of study drug, whichever is later; for men, these restrictions apply for 12 months after the last dose of rituximab or 3 months after the last dose of study drug, whichever is later) - Men must agree to not donate sperm during and after the study for 12 months after the last dose of rituximab or 3 months after the last dose of study drug, whichever is later - Women of childbearing potential must have a negative serum or urine pregnancy test at screening Exclusion Criteria: - Major surgery within 4 weeks of random assignment - Known central nervous system or primary mediastinal lymphoma - Prior history of indolent lymphoma - Diagnosed or treated for malignancy other than DLBCL, except: malignancy treated with curative intent and with no known active disease present for >=3 years before random assignment; adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease; adequately treated carcinoma in situ without evidence of disease - History of stroke or intracranial hemorrhage within 6 months prior to random assignment - Requires anticoagulation with warfarin or equivalent vitamin K antagonists - Requires treatment with strong CYP3A inhibitors - Prior anthracycline use >=150 mg/m2 - Clinically significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening, or any Class 3 (moderate) or Class 4 (severe) cardiac disease as defined by the New York Heart Association Functional Classification - Known history of human immunodeficiency virus or active hepatitis C virus or active hepatitis B virus infection or any uncontrolled active systemic infection requiring intravenous antibiotics - Women who are pregnant or breastfeeding - Any life-threatening illness, medical condition, or organ system dysfunction which, in the investigator's opinion, could compromise the patient's safety, interfere with the absorption or metabolism of ibrutinib capsules, or put the study outcomes at undue risk |
| Gender | Both |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Contact: Use link at the bottom of the page to see if you qualify for an enrolling site (see list). If you still have questions: JNJ.CT@sylogent.com |
| Location Countries | United States, Argentina, Australia, Belgium, Brazil, Canada, China, Czech Republic, Denmark, Finland, France, Germany, Hungary, Israel, Japan, Korea, Republic of, Mexico, Netherlands, Norway, Poland, Russian Federation, Spain, Sweden, Taiwan, Turkey, Ukraine, United Kingdom |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01855750 |
|---|---|
| Other Study ID Numbers | CR102118 |
| Has Data Monitoring Committee | Yes |
| Information Provided By | Janssen Research & Development, LLC |
| Study Sponsor | Janssen Research & Development, LLC |
| Collaborators | Pharmacyclics |
| Investigators | Study Director: Janssen Research & Development, LLC Clinical Trial Janssen Research & Development, LLC |
| Verification Date | April 2014 |
Locations[ + expand ][ + ]
| United States, Arizona | Tucson, Arizona, United States Not yet recruiting |
|---|---|
| United States, California | Burbank, California, United States Withdrawn |
| United States, California | Greenbrae, California, United States Recruiting |
| United States, California | La Jolla, California, United States Not yet recruiting |
| United States, California | Los Angeles, California, United States Withdrawn |
| United States, California | Los Angeles, California, United States Not yet recruiting |
| United States, California | Salinas, California, United States Recruiting |
| United States, California | Stanford, California, United States Not yet recruiting |
| United States, Connecticut | Danbury, Connecticut, United States Recruiting |
| United States, Connecticut | Hartford, Connecticut, United States Recruiting |
| United States, Connecticut | Middletown, Connecticut, United States Withdrawn |
| United States, District of Columbia | Washington, District of Columbia, United States Recruiting |
| United States, Florida | Palm Beach Gardens, Florida, United States Withdrawn |
| United States, Florida | Tampa, Florida, United States Withdrawn |
| United States, Georgia | Atlanta, Georgia, United States Recruiting |
| United States, Georgia | Marietta, Georgia, United States Recruiting |
| United States, Idaho | Post Falls, Idaho, United States Withdrawn |
| United States, Illinois | Chicago, Illinois, United States Withdrawn |
| United States, Illinois | Maywood, Illinois, United States Withdrawn |
| United States, Illinois | Peoria, Illinois, United States Recruiting |
| United States, Indiana | Fort Wayne, Indiana, United States Recruiting |
| United States, Indiana | Goshen, Indiana, United States Recruiting |
| United States, Indiana | Indianapolis, Indiana, United States Recruiting |
| United States, Kansas | Topeka, Kansas, United States Recruiting |
| United States, Kentucky | Louisville, Kentucky, United States Recruiting |
| United States, Louisiana | Baton Rouge, Louisiana, United States Recruiting |
| United States, Louisiana | Metairie, Louisiana, United States Withdrawn |
| United States, Louisiana | New Orleans, Louisiana, United States Recruiting |
| United States, Maryland | Baltimore, Maryland, United States Withdrawn |
| United States, Maryland | Baltimore, Maryland, United States Recruiting |
| United States, Maryland | Bethesda, Maryland, United States Recruiting |
| United States, Maryland | Bethesda, Maryland, United States Not yet recruiting |
| United States, Maryland | Rockville, Maryland, United States Withdrawn |
| United States, Massachusetts | Boston, Massachusetts, United States Recruiting |
| United States, Massachusetts | Boston, Massachusetts, United States Withdrawn |
| United States, Massachusetts | Boston, Massachusetts, United States Not yet recruiting |
| United States, Michigan | Ann Arbor, Michigan, United States Recruiting |
| United States, Missouri | St. Louis, Missouri, United States Recruiting |
| United States, Nebraska | Omaha, Nebraska, United States Not yet recruiting |
| United States, New Jersey | Hackensack, New Jersey, United States Recruiting |
| United States, New Jersey | New Brunswick, New Jersey, United States Recruiting |
| United States, New York | Bronx, New York, United States Recruiting |
| United States, New York | Fresh Meadows, New York, United States Recruiting |
| United States, New York | Johnson City, New York, United States Recruiting |
| United States, New York | Mineola, New York, United States Recruiting |
| United States, New York | New York, New York, United States Recruiting |
| United States, New York | New York, New York, United States Not yet recruiting |
| United States, New York | Rochester, New York, United States Recruiting |
| United States, North Carolina | Charlotte, North Carolina, United States Not yet recruiting |
| United States, North Carolina | Charlotte, North Carolina, United States Recruiting |
| United States, North Carolina | Goldsboro, North Carolina, United States Withdrawn |
| United States, North Carolina | Greenville, North Carolina, United States Recruiting |
| United States, North Carolina | Hickory, North Carolina, United States Recruiting |
| United States, Ohio | Cincinnati, Ohio, United States Withdrawn |
| United States, Ohio | Columbus, Ohio, United States Not yet recruiting |
| United States, Oregon | Portland, Oregon, United States Recruiting |
| United States, Pennsylvania | Philadelphia, Pennsylvania, United States Withdrawn |
| United States, Pennsylvania | Pittsburgh, Pennsylvania, United States Withdrawn |
| United States, South Carolina | N Charleston, South Carolina, United States Recruiting |
| United States, Tennessee | Nashville, Tennessee, United States Withdrawn |
| United States, Tennessee | Nashville, Tennessee, United States Not yet recruiting |
| United States, Texas | Houston, Texas, United States Not yet recruiting |
| United States, Texas | Houston, Texas, United States Recruiting |
| United States, Texas | Temple, Texas, United States Recruiting |
| United States, Utah | Salt Lake City, Utah, United States Withdrawn |
| United States, Vermont | Burlington, Vermont, United States Recruiting |
| United States, Virginia | Charlottesville, Virginia, United States Withdrawn |
| United States, Washington | Seattle, Washington, United States Not yet recruiting |
| United States, Wisconsin | Marshfield, Wisconsin, United States Withdrawn |
| Argentina | Buenos Aires, Argentina Recruiting |
| Argentina | Capital Federal, Argentina Withdrawn |
| Argentina | Ciudad Autonoma Buenos Aires, Argentina Recruiting |
| Argentina | Ciudad De Buenos Aires, Argentina Recruiting |
| Argentina | Cordoba, Argentina Not yet recruiting |
| Argentina | Córdoba, Argentina Withdrawn |
| Argentina | La Capital, Argentina Recruiting |
| Argentina | La Plata, Argentina Not yet recruiting |
| Argentina | Parana, Argentina Withdrawn |
| Australia | Adelaide, Australia Recruiting |
| Australia | Concord, Australia Recruiting |
| Australia | Darlinghurst, Australia Recruiting |
| Australia | Douglas, Australia Withdrawn |
| Australia | Freemantle, Australia Recruiting |
| Australia | Hobart, Tasmania, Australia Recruiting |
| Australia | Melbourne, Australia Recruiting |
| Australia | Nedlands, Australia Recruiting |
| Australia | Perth, Australia Withdrawn |
| Australia | Randwick, Australia Recruiting |
| Australia | South Brisbane, Australia Recruiting |
| Australia | Woden, Australia Withdrawn |
| Australia | Woolloongabba, Australia Recruiting |
| Belgium | Antwerpen, Belgium Recruiting |
| Belgium | Brugge, Belgium Recruiting |
| Belgium | Brussel, Belgium Recruiting |
| Belgium | Gent, Belgium Recruiting |
| Belgium | Haine-Saint-Paul, La Louviere, Belgium Recruiting |
| Belgium | Kortrijk, Belgium Recruiting |
| Belgium | Leuven, Belgium Recruiting |
| Brazil | Brasília, Brazil Withdrawn |
| Brazil | Campinas, Brazil Withdrawn |
| Brazil | Curitiba, Brazil Withdrawn |
| Brazil | Jau, Brazil Withdrawn |
| Brazil | Porto Alegre, Brazil Withdrawn |
| Brazil | Porto Alegre, Brazil Not yet recruiting |
| Brazil | Ribeirão Preto, Brazil Withdrawn |
| Brazil | Rio De Janeiro, Brazil Not yet recruiting |
| Brazil | Sao Paulo, Brazil Not yet recruiting |
| Brazil | Sao Paulo, Brazil Recruiting |
| Brazil | São José Do Rio Preto, Brazil Withdrawn |
| Brazil | São Paulo, Brazil Not yet recruiting |
| Canada, Alberta | Edmonton, Alberta, Canada Not yet recruiting |
| Canada, British Columbia | Vancouver, British Columbia, Canada Recruiting |
| Canada, Manitoba | Winnipeg, Manitoba, Canada Withdrawn |
| Canada, Nova Scotia | Halifax, Nova Scotia, Canada Not yet recruiting |
| Canada, Ontario | Hamilton, Ontario, Canada Withdrawn |
| Canada, Ontario | Toronto, Ontario, Canada Not yet recruiting |
| Canada, Ontario | Toronto, Ontario, Canada Withdrawn |
| Canada, Quebec | Levis, Quebec, Canada Recruiting |
| Canada, Quebec | Montreal, Quebec, Canada Not yet recruiting |
| China | Beijing, China Not yet recruiting |
| China | Beijing, China Recruiting |
| China | Chengdu, China Not yet recruiting |
| China | Guangzhou, China Recruiting |
| China | Shanghai, China Recruiting |
| China | Tianjin, China Recruiting |
| China | Tianjin, China Withdrawn |
| Czech Republic | Brno, Czech Republic Not yet recruiting |
| Czech Republic | Hradec Kralove, Czech Republic Recruiting |
| Czech Republic | Ostrava, Czech Republic Recruiting |
| Czech Republic | Praha 10, Czech Republic Recruiting |
| Czech Republic | Praha 2, Czech Republic Not yet recruiting |
| Denmark | Aarhus C, Denmark Recruiting |
| Denmark | Copenhagen, Denmark Recruiting |
| Denmark | Roskilde, Denmark Recruiting |
| Denmark | Vejle, Denmark Recruiting |
| Finland | Helsinki, Finland Recruiting |
| Finland | Jyväskylä, Finland Recruiting |
| Finland | Oulu, Finland Recruiting |
| Finland | Turku, Finland Recruiting |
| France | Grenoble Cedex 9, France Recruiting |
| France | Limoges, France Recruiting |
| France | Montpellier, France Withdrawn |
| France | Nantes Cedex 1, France Withdrawn |
| France | Paris, France Recruiting |
| France | Pessac, France Recruiting |
| France | Tours, France Recruiting |
| France | Villejuif, France Recruiting |
| Germany | Bamberg, Germany Not yet recruiting |
| Germany | Berlin, Germany Not yet recruiting |
| Germany | Dresden, Germany Not yet recruiting |
| Germany | Essen, Germany Not yet recruiting |
| Germany | Frankfurt, Germany Not yet recruiting |
| Germany | Frankfurt / Main, Germany Withdrawn |
| Germany | Fulda, Germany Not yet recruiting |
| Germany | Hannover, Germany Withdrawn |
| Germany | Heidelberg, Germany Withdrawn |
| Germany | Jena, Germany Not yet recruiting |
| Germany | Mainz, Germany Withdrawn |
| Germany | Muenchen, Germany Not yet recruiting |
| Germany | Münster, Germany Not yet recruiting |
| Germany | Villingen-Schwenningen, Germany Not yet recruiting |
| Hungary | Budapest N/A, Hungary Recruiting |
| Hungary | Debrecen, Hungary Recruiting |
| Hungary | Gyula, Hungary Recruiting |
| Hungary | Szekesfehervar, Hungary Withdrawn |
| Hungary | Szombathely, Hungary Recruiting |
| Hungary | Veszprem, Hungary Recruiting |
| Israel | Beer-Sheva, Israel Not yet recruiting |
| Israel | Hadera, Israel Not yet recruiting |
| Israel | Haifa, Israel Not yet recruiting |
| Israel | Nahariya, Israel Suspended |
| Israel | Petah Tikva, Israel Not yet recruiting |
| Israel | Ramat-Gan, Israel Not yet recruiting |
| Israel | Tel Aviv, Israel Not yet recruiting |
| Japan | Fukuoka, Japan Recruiting |
| Japan | Hiroshima, Japan Recruiting |
| Japan | Isehara, Japan Withdrawn |
| Japan | Kyoto, Japan Recruiting |
| Japan | Nagoya, Japan Withdrawn |
| Japan | Nagoya, Japan Recruiting |
| Japan | Osaka, Japan Recruiting |
| Japan | Sapporo, Japan Recruiting |
| Japan | Sendai, Japan Recruiting |
| Japan | Suita, Japan Recruiting |
| Japan | Tokyo, Japan Recruiting |
| Korea, Republic of | Busan, Korea, Republic of Recruiting |
| Korea, Republic of | Goyang, Korea, Republic of Recruiting |
| Korea, Republic of | Seognam-Si, Kyungki-Do, Korea, Republic of Withdrawn |
| Korea, Republic of | Seoul, Korea, Republic of Recruiting |
| Mexico | Mexico, Mexico Withdrawn |
| Mexico | Mexico, Mexico Not yet recruiting |
| Mexico | Monterrey, Mexico Recruiting |
| Mexico | Monterrey, Mexico Not yet recruiting |
| Mexico | San Luis Potosi, Mexico Not yet recruiting |
| Mexico | Zapopan, Mexico Withdrawn |
| Netherlands | Amsterdam Zuidoost, Netherlands Recruiting |
| Netherlands | Arnhem, Netherlands Recruiting |
| Netherlands | Dordrecht, Netherlands Recruiting |
| Netherlands | Groningen, Netherlands Recruiting |
| Netherlands | Leiden, Netherlands Recruiting |
| Netherlands | Nieuwegein, Netherlands Recruiting |
| Netherlands | Rotterdam, Netherlands Recruiting |
| Norway | Bergen, Norway Withdrawn |
| Norway | Oslo, Norway Recruiting |
| Norway | Tromsø, Norway Recruiting |
| Poland | Brzozow, Poland Recruiting |
| Poland | Chorzów, Poland Recruiting |
| Poland | Gdynia, Poland Suspended |
| Poland | Krakow, Poland Recruiting |
| Poland | Lodz, Poland Recruiting |
| Poland | Lublin, Poland Suspended |
| Poland | Olsztyn, Poland Recruiting |
| Poland | Poznan, Poland Recruiting |
| Poland | Warszawa, Poland Recruiting |
| Poland | Wroclaw, Poland Recruiting |
| Russian Federation | Chelyabinsk, Russian Federation Withdrawn |
| Russian Federation | Ekaterinburg, Russian Federation Completed |
| Russian Federation | Krasnodar, Russian Federation Withdrawn |
| Russian Federation | Moscow, Russian Federation Recruiting |
| Russian Federation | Moscow N/A, Russian Federation Recruiting |
| Russian Federation | Nizhny Novgorod, Russian Federation Recruiting |
| Russian Federation | Rostov-Na-Donu, Russian Federation Recruiting |
| Russian Federation | Saint Petersburg, Russian Federation Withdrawn |
| Russian Federation | Sochi, Russian Federation Recruiting |
| Russian Federation | St. Petersburg, Russian Federation Recruiting |
| Russian Federation | Volgograd, Russian Federation Recruiting |
| Spain | Barcelona, Spain Recruiting |
| Spain | Madrid, Spain Recruiting |
| Spain | Madrid, Spain Withdrawn |
| Spain | Salamanca, Spain Recruiting |
| Spain | Sevilla, Spain Recruiting |
| Sweden | Karlstad, Sweden Withdrawn |
| Sweden | Linköping, Sweden Recruiting |
| Sweden | Luleå, Sweden Recruiting |
| Sweden | Lund, Sweden Not yet recruiting |
| Sweden | Uppsala, Sweden Recruiting |
| Taiwan | Changhua, Taiwan Withdrawn |
| Taiwan | Taichung, Taiwan Recruiting |
| Taiwan | Tainan, Taiwan Recruiting |
| Taiwan | Tainan, Taiwan Not yet recruiting |
| Taiwan | Taipei, Taiwan Withdrawn |
| Taiwan | Taoyuan County, Taiwan Recruiting |
| Turkey | Adana, Turkey Recruiting |
| Turkey | Ankara, Turkey Recruiting |
| Turkey | Edirne, Turkey Withdrawn |
| Turkey | Istanbul, Turkey Not yet recruiting |
| Turkey | Izmir, Turkey Recruiting |
| Turkey | Kayseri, Turkey Recruiting |
| Turkey | Samsun, Turkey Recruiting |
| Ukraine | Cherkassy, Ukraine Recruiting |
| Ukraine | Dnepropetrovsk, Ukraine Not yet recruiting |
| Ukraine | Donetsk, Ukraine Not yet recruiting |
| Ukraine | Khmelnitskiy, Ukraine Recruiting |
| Ukraine | Kiev, Ukraine Not yet recruiting |
| Ukraine | Kiev, Ukraine Recruiting |
| Ukraine | Lviv, Ukraine Recruiting |
| Ukraine | Makiivka, Ukraine Recruiting |
| Ukraine | Simferopol, Ukraine Not yet recruiting |
| United Kingdom | Glasgow, United Kingdom Not yet recruiting |
| United Kingdom | Liverpool, United Kingdom Recruiting |
| United Kingdom | London, United Kingdom Withdrawn |
| United Kingdom | London, United Kingdom Recruiting |
| United Kingdom | Maidstone, United Kingdom Not yet recruiting |
| United Kingdom | Manchester, United Kingdom Recruiting |
| United Kingdom | Nottingham, United Kingdom Recruiting |
| United Kingdom | Oxford, United Kingdom Recruiting |
| United Kingdom | Romford, United Kingdom Recruiting |
| United Kingdom | Southampton, United Kingdom Recruiting |