Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32
Overview[ - collapse ][ - ]
| Purpose | RATIONALE: Studying samples of blood in the laboratory from patients with breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to fatigue. PURPOSE: This research study is studying biomarkers associated with fatigue in patients with early-stage breast cancer treated with metformin or placebo on NCIC-CTG-MA.32. |
|---|---|
| Condition | Breast Cancer Depression Fatigue Sleep Disorders |
| Intervention | Drug: Metformin Drug: Placebo |
| Phase | N/A |
| Sponsor | National Surgical Adjuvant Breast and Bowel Project (NSABP) |
| Responsible Party | National Surgical Adjuvant Breast and Bowel Project (NSABP) |
| ClinicalTrials.gov Identifier | NCT01286233 |
| First Received | January 27, 2011 |
| Last Updated | May 17, 2013 |
| Last verified | May 2013 |
Tracking Information[ + expand ][ + ]
| First Received Date | January 27, 2011 |
|---|---|
| Last Updated Date | May 17, 2013 |
| Start Date | July 2011 |
| Estimated Primary Completion Date | September 2016 |
| Current Primary Outcome Measures |
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| Current Secondary Outcome Measures | Not Provided |
Descriptive Information[ + expand ][ + ]
| Brief Title | Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32 |
|---|---|
| Official Title | Biobehavioral Mechanisms of Fatigue in Patients Treated on NCIC CTG MA.32: A Phase III Randomized Trial of Metformin Versus Placebo on Recurrence and Survival in Early Stage Breast Cancer |
| Brief Summary | RATIONALE: Studying samples of blood in the laboratory from patients with breast cancer may help doctors learn more about changes that occur in DNA and identify biomarkers related to fatigue. PURPOSE: This research study is studying biomarkers associated with fatigue in patients with early-stage breast cancer treated with metformin or placebo on NCIC-CTG-MA.32. |
| Detailed Description | OBJECTIVES: - To prepare, separate into components, and store the blood specimens at the NSABP Serum Bank at Baylor College of Medicine Breast Center for future DNA, RNA, and plasma analysis, and to analyze specific proinflammatory cytokines, genetic polymorphisms, and RNA expression arrays in collaborating laboratories at University of California, Los Angeles (UCLA). - To examine the association between markers of inflammation and symptoms of fatigue among patients with and without exposure to metformin hydrochloride. - To examine the relationship between single nucleotide polymorphism (SNPs) in the promoter regions of IL-1 and IL-6 and symptoms of fatigue with and without exposure to metformin hydrochloride. - To examine RNA expression profiles in relationship to fatigue and compare the pattern of expression in patients with and without exposure to metformin hydrochloride. - To determine the biological and behavioral predictors of fatigue in breast cancer patients in the five years post-randomization. - To determine whether metformin is associated with reductions in inflammatory markers and corresponding decreases in fatigue. (Exploratory) OUTLINE: This is a multicenter study. Patients' serum and plasma, collected at baseline and at 6, 12, and 24 months after NCIC CTG MA.32 randomization, are analyzed for inflammatory markers, DNA polymorphisms, and RNA expression arrays by ELISA, TaqMan PCR, and RT-PCR. Patients complete the Fatigue Symptom Inventory (symptoms associated with fatigue, sleep disturbance, depression, and endocrine therapy) at baseline and periodically during study. |
| Study Type | Observational |
| Study Phase | N/A |
| Study Design | Observational Model: Case Control, Time Perspective: Prospective |
| Condition |
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| Intervention | Drug: Metformin Drug: Placebo |
| Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
| Recruitment Status | Active, not recruiting |
|---|---|
| Estimated Enrollment | 394 |
| Estimated Completion Date | September 2016 |
| Estimated Primary Completion Date | September 2016 |
| Eligibility Criteria | Inclusion Criteria - The patient must have consented to participate and must have signed and dated an appropriate IRB-approved consent form that conforms to federal and institutional guidelines for the MA.32.F Study before being enrolled. - The patient must be female. - The patient must reside in the United States or Canada. - The patient must be English-speaking. - The patient must be eligible for randomization in the MA.32 treatment trial. (Participation in the MA.32 QOL study is permitted but not required.) - The patient must not have started taking MA.32 study therapy. - The patient must have completed primary breast radiation therapy at least two weeks prior to enrollment in MA.32.F. Exclusion Criteria - MA.32 study therapy has been initiated. - Currently receiving radiation therapy or additional radiation therapy is planned for initiation after starting MA.32 study therapy. |
| Gender | Female |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Not Provided |
| Location Countries | United States, Canada |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01286233 |
|---|---|
| Other Study ID Numbers | NSABP MA.32.F |
| Has Data Monitoring Committee | No |
| Information Provided By | National Surgical Adjuvant Breast and Bowel Project (NSABP) |
| Study Sponsor | National Surgical Adjuvant Breast and Bowel Project (NSABP) |
| Collaborators | National Cancer Institute (NCI) |
| Investigators | Principal Investigator: Norman Wolmark, MD NSABP Foundation, Inc. |
| Verification Date | May 2013 |
Locations[ + expand ][ + ]
| Kaiser Permanente Medical Center - Anaheim/Orange County | Anaheim, California, United States, 92807 |
|---|---|
| Kaiser Permanente - Deer Valley | Antioch, California, United States, 94531 |
| Kaiser Permanente Medical Center - Baldwin Park | Baldwin Park, California, United States, 91706 |
| Kaiser Permanente Medical Center - Bellflower | Bellflower, California, United States, 90706 |
| Kaiser Permanente Medical Center - Fontana | Fontana, California, United States, 92335 |
| Kaiser Permanente - Fremont | Fremont, California, United States, 94538 |
| Kaiser Permanente Medical Center - Harbor City | Harbor City, California, United States, 90710 |
| Kaiser Permanente Medical Center - Hayward | Hayward, California, United States, 94545 |
| Kaiser Permanente - Irvine | Irvine, California, United States, 92618 |
| Kaiser Foundation Hospital - West Los Angeles | Los Angeles, California, United States, 90034 |
| Kaiser Permanente Medical Center - Los Angeles | Los Angeles, California, United States, 90027 |
| Kaiser Permanente Medical Center - Oakland | Oakland, California, United States, 94611 |
| Kaiser Permanente - Ontario Vineyard Medical Offices and Ambulatory SurgiCenter | Ontario, California, United States, 91761 |
| Kaiser Permanente Medical Group | Panorama City, California, United States, 91402 |
| Kaiser Permanente Medical Center - Redwood City | Redwood City, California, United States, 94063 |
| Kaiser Permanente Medical Center - Richmond | Richmond, California, United States, 94801 |
| Kaiser Permanente Medical Center - Riverside | Riverside, California, United States, 92505 |
| Kaiser Permanente Medical Center - Roseville | Roseville, California, United States, 95661 |
| South Sacramento Kaiser-Permanente Medical Center | Sacramento, California, United States, 95823 |
| Kaiser Permanente Medical Center - Sacramento | Sacramento, California, United States, 95825 |
| Kaiser Permanente Medical Office -Vandever Medical Office | San Diego, California, United States, 92108 |
| Kaiser Permanente Medical Center - Kaiser Foundation Hospital - San Diego | San Diego, California, United States, 92120 |
| Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco, California, United States, 94115 |
| Kaiser Permanente Medical Center - Santa Teresa | San Jose, California, United States, 95119 |
| Kaiser Permanente Health Care | San Marcos, California, United States, 92078 |
| Kaiser Foundation Hospital - San Rafael | San Rafael, California, United States, 94903 |
| Kaiser Permanente Medical Center - Santa Clara Kiely Campus | Santa Clara, California, United States, 95051 |
| Kaiser Permanente Medical Center - Santa Rosa | Santa Rosa, California, United States, 95403 |
| Kaiser Permanente Medical Center - South San Francisco | South San Francisco, California, United States, 94080 |
| Kaiser Permanente Medical Facility - Stockton | Stockton, California, United States, 95210 |
| Kaiser Permanente Medical Center - Vacaville | Vacaville, California, United States, 95688 |
| Kaiser Permanente Medical Center - Vallejo | Vallejo, California, United States, 94589 |
| Kaiser Permanente Medical Center - Walnut Creek | Walnut Creek, California, United States, 94596 |
| Kaiser Permanente Medical Cener - Woodland Hills | Woodland Hills, California, United States, 91367 |
| Front Range Cancer Specialists | Fort Collins, Colorado, United States, 80528 |
| Poudre Valley Hospital | Fort Collins, Colorado, United States, 80524 |
| Lombardi Comprehensive Cancer Center at Georgetown University Medical Center | Washington, District of Columbia, United States, 20007 |
| Phoebe Cancer Center at Phoebe Putney Memorial Hospital | Albany, Georgia, United States, 31701 |
| Northeast Georgia Medical Center | Gainesville, Georgia, United States, 30501 |
| Kaiser Permanente - Moanalua Medical Center and Clinic | Honolulu, Hawaii, United States, 96819 |
| St. Joseph Regional Medical Center | Lewiston, Idaho, United States, 83501 |
| Rush-Copley Cancer Care Center | Aurora, Illinois, United States, 60504 |
| St. Joseph Medical Center | Bloomington, Illinois, United States, 61701 |
| Illinois CancerCare - Bloomington | Bloomington%, Illinois, United States, 61701 |
| Illinois CancerCare - Canton | Canton, Illinois, United States, 61520 |
| Graham Hospital | Canton, Illinois, United States, 61520 |
| Illinois CancerCare - Carthage | Carthage, Illinois, United States, 62321 |
| Memorial Hospital | Carthage, Illinois, United States, 62321 |
| Resurrection Medical Center | Chicago, Illinois, United States, 60631 |
| Decatur Memorial Hospital Cancer Care Institute | Decatur, Illinois, United States, 62526 |
| Eureka Community Hospital | Eureka, Illinois, United States, 61530 |
| Illinois CancerCare - Eureka | Eureka, Illinois, United States, 61530 |
| Evanston Hospital | Evanston, Illinois, United States, 60201-1781 |
| Galesburg Clinic, PC | Galesburg, Illinois, United States, 61401 |
| Illinois CancerCare - Galesburg | Galesburg, Illinois, United States, 61401 |
| Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey, Illinois, United States, 60426 |
| Mason District Hospital | Havana, Illinois, United States, 62644 |
| Illinois CancerCare - Havana | Havana, Illinois, United States, 62644 |
| Illinois CancerCare - Kewanee Clinic | Kewanee, Illinois, United States, 61443 |
| Illinois CancerCare - Macomb | Macomb, Illinois, United States, 61455 |
| McDonough District Hospital | Macomb, Illinois, United States, 61455 |
| Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood, Illinois, United States, 60153 |
| United States, Illinois | Moline, Illinois, United States, 61265 |
| Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline, Illinois, United States, 61265 |
| OSF Holy Family Medical Center | Monmouth, Illinois, United States, 61462 |
| Illinois CancerCare - Monmouth | Monmouth, Illinois, United States, 61462 |
| Good Samaritan Regional Health Center | Mount Vernon, Illinois, United States, 62864 |
| BroMenn Regional Medical Center | Normal, Illinois, United States, 61761 |
| Community Cancer Center | Normal, Illinois, United States, 61761 |
| Illinois CancerCare - Community Cancer Center | Normal, Illinois, United States, 61761 |
| Community Hospital of Ottawa | Ottawa, Illinois, United States, 61350 |
| Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa, Illinois, United States, 61350 |
| Illinois CancerCare - Pekin | Pekin, Illinois, United States, 61603 |
| Cancer Treatment Center at Pekin Hospital | Pekin, Illinois, United States, 61554 |
| Methodist Medical Center of Illinois | Peoria, Illinois, United States, 61636 |
| CCOP - Illinois Oncology Research Association | Peoria, Illinois, United States, 61615 |
| Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria, Illinois, United States, 61615 |
| Proctor Hospital | Peoria, Illinois, United States, 61614 |
| OSF St. Francis Medical Center | Peoria, Illinois, United States, 61637 |
| Illinois Valley Community Hospital | Peru, Illinois, United States, 61354 |
| Illinois CancerCare - Peru | Peru, Illinois, United States, 61354 |
| Perry Memorial Hospital | Princeton, Illinois, United States, 61356 |
| Illinois CancerCare - Princeton | Princeton, Illinois, United States, 61356 |
| Illinois CancerCare - Spring Valley | Spring Valley, Illinois, United States, 61362 |
| Regional Cancer Center at Memorial Medical Center | Springfield, Illinois, United States, 62781-0001 |
| CCOP - Carle Cancer Center | Urbana, Illinois, United States, 61801 |
| Central Dupage Cancer Center | Warrenville, Illinois, United States, 60555 |
| Elkhart Clinic, LLC | Elkhart, Indiana, United States, 46514-2098 |
| Michiana Hematology-Oncology, PC - Elkhart | Elkhart, Indiana, United States, 46514 |
| Elkhart General Hospital | Elkhart, Indiana, United States, 46515 |
| Howard Community Hospital | Kokomo, Indiana, United States, 46904 |
| Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte, Indiana, United States, 46350 |
| Saint Anthony Memorial Health Centers | Michigan City, Indiana, United States, 46360 |
| Michiana Hematology-Oncology, PC - South Bend | Mishawaka, Indiana, United States, 46545-1470 |
| Saint Joseph Regional Medical Center | Mishawaka, Indiana, United States, 46545-1470 |
| Michiana Hematology Oncology PC - Plymouth | Plymouth, Indiana, United States, 46563 |
| Memorial Hospital of South Bend | South Bend, Indiana, United States, 46601 |
| CCOP - Northern Indiana CR Consortium | South Bend, Indiana, United States, 46601 |
| Michiana Hematology Oncology PC - La Porte | Westville, Indiana, United States, 46391 |
| United States, Iowa | Bettendorf, Iowa, United States, 52722 |
| Mercy Regional Cancer Center at Mercy Medical Center | Cedar Rapids, Iowa, United States, 52403 |
| Cedar Rapids Oncology Associates | Cedar Rapids, Iowa, United States, 52403 |
| McCreery Cancer Center at Ottumwa Regional | Ottumwa, Iowa, United States, 52501 |
| Mercy Medical Center - Sioux City | Sioux City, Iowa, United States, 51102 |
| Siouxland Hematology-Oncology Associates, LLP | Sioux City, Iowa, United States, 51101 |
| St. Luke's Regional Medical Center | Sioux City, Iowa, United States, 51104 |
| Cancer Center of Kansas, PA - Chanute | Chanute, Kansas, United States, 66720 |
| Cancer Center of Kansas, PA - Dodge City | Dodge City, Kansas, United States, 67801 |
| Cancer Center of Kansas, PA - El Dorado | El Dorado, Kansas, United States, 67042 |
| Cancer Center of Kansas - Fort Scott | Fort Scott, Kansas, United States, 66701 |
| Cancer Center of Kansas-Independence | Independence, Kansas, United States, 67301 |
| Cancer Center of Kansas, PA - Kingman | Kingman, Kansas, United States, 67068 |
| Lawrence Memorial Hospital | Lawrence, Kansas, United States, 66044 |
| Cancer Center of Kansas, PA - Liberal | Liberal, Kansas, United States, 67901 |
| Cancer Center of Kansas, PA - McPherson | McPherson, Kansas, United States, 67460 |
| Cancer Center of Kansas, PA - Newton | Newton, Kansas, United States, 67114 |
| Cancer Center of Kansas, PA - Parsons | Parsons, Kansas, United States, 67357 |
| Cancer Center of Kansas, PA - Pratt | Pratt, Kansas, United States, 67124 |
| Cancer Center of Kansas, PA - Salina | Salina, Kansas, United States, 67401 |
| Cancer Center of Kansas, PA - Wellington | Wellington, Kansas, United States, 67152 |
| Cancer Center of Kansas, PA - Wichita | Wichita, Kansas, United States, 67214 |
| Cancer Center of Kansas, PA - Medical Arts Tower | Wichita, Kansas, United States, 67208 |
| Associates in Womens Health, PA - North Review | Wichita, Kansas, United States, 67208 |
| CCOP - Wichita | Wichita, Kansas, United States, 67214 |
| Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita, Kansas, United States, 67214 |
| Cancer Center of Kansas, PA - Winfield | Winfield, Kansas, United States, 67156 |
| Central Baptist Hospital | Lexington, Kentucky, United States, 40503-9985 |
| York Hospital's Oncology Treatment Center | York, Maine, United States, 03909 |
| Frederick Memorial Hospital Regional Cancer Therapy Center | Frederick, Maryland, United States, 21701 |
| Addison Gilbert Hospital | Gloucester, Massachusetts, United States, 01930 |
| Lowell General Hospital | Lowell, Massachusetts, United States, 01854 |
| Battle Creek Health System Cancer Care Center | Battle Creek, Michigan, United States, 49017 |
| Mecosta County Medical Center | Big Rapids, Michigan, United States, 49307 |
| Green Bay Oncology, Limited - Escanaba | Escanaba, Michigan, United States, 49431 |
| CCOP - Grand Rapids | Grand Rapids, Michigan, United States, 49503 |
| Lacks Cancer Center at Saint Mary's Health Care | Grand Rapids, Michigan, United States, 49503 |
| Butterworth Hospital at Spectrum Health | Grand Rapids, Michigan, United States, 49503 |
| Dickinson County Healthcare System | Iron Mountain, Michigan, United States, 49801 |
| Mercy General Health Partners | Muskegon, Michigan, United States, 49444 |
| Spectrum Health Reed City Hospital | Reed City, Michigan, United States, 49677 |
| William Beaumont Hospital - Royal Oak Campus | Royal Oak, Michigan, United States, 48073 |
| Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph, Michigan, United States, 49085 |
| Lakeside Cancer Specialists, PLLC | Saint Joseph, Michigan, United States, 49085 |
| Munson Medical Center | Traverse City, Michigan, United States, 49684 |
| St. Joseph's Medical Center | Brainerd, Minnesota, United States, 56401 |
| Fairview Ridges Hospital | Burnsville, Minnesota, United States, 55337 |
| Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids, Minnesota, United States, 55433 |
| CCOP - Duluth | Duluth, Minnesota, United States, 55805 |
| Duluth Clinic Cancer Center - Duluth | Duluth, Minnesota, United States, 55805-1983 |
| Miller - Dwan Medical Center | Duluth, Minnesota, United States, 55805 |
| Fairview Southdale Hospital | Edina, Minnesota, United States, 55435 |
| Mercy and Unity Cancer Center at Unity Hospital | Fridley, Minnesota, United States, 55432 |
| Hutchinson Area Health Care | Hutchinson, Minnesota, United States, 55350 |
| HealthEast Cancer Care at St. John's Hospital | Maplewood, Minnesota, United States, 55109 |
| Minnesota Oncology - Maplewood | Maplewood, Minnesota, United States, 55109 |
| Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis, Minnesota, United States, 55407 |
| Hennepin County Medical Center - Minneapolis | Minneapolis, Minnesota, United States, 55415 |
| New Ulm Medical Center | New Ulm, Minnesota, United States, 56073 |
| Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale, Minnesota, United States, 55422-2900 |
| Coborn Cancer Center | Saint Cloud, Minnesota, United States, 56303 |
| CentraCare Clinic - River Campus | Saint Cloud, Minnesota, United States, 56303 |
| Park Nicollet Cancer Center | Saint Louis Park, Minnesota, United States, 55416 |
| CCOP - Metro-Minnesota | Saint Louis Park, Minnesota, United States, 55416 |
| United Hospital | Saint Paul, Minnesota, United States, 55102 |
| St. Francis Cancer Center at St. Francis Medical Center | Shakopee, Minnesota, United States, 55379 |
| Regions Hospital Cancer Care Center | St. Paul, Minnesota, United States, 55101 |
| Lakeview Hospital | Stillwater, Minnesota, United States, 55082 |
| Ridgeview Medical Center | Waconia, Minnesota, United States, 55387 |
| Willmar Cancer Center at Rice Memorial Hospital | Willmar, Minnesota, United States, 56201 |
| Minnesota Oncology - Woodbury | Woodbury, Minnesota, United States, 55125 |
| Saint Luke's Hospital | Chesterfield, Missouri, United States, 63017 |
| CCOP - St. Louis-Cape Girardeau | Saint Louis, Missouri, United States, 63141 |
| David C. Pratt Cancer Center at St. John's Mercy | Saint Louis, Missouri, United States, 63141 |
| Midwest Hematology Oncology Group, Incorporated | Saint Louis, Missouri, United States, 63109 |
| Good Samaritan Cancer Center at Good Samaritan Hospital | Kearney, Nebraska, United States, 68848-1990 |
| Cancer Resource Center - Lincoln | Lincoln, Nebraska, United States, 68510 |
| CCOP - Missouri Valley Cancer Consortium | Omaha, Nebraska, United States, 68106 |
| Creighton University Medical Center | Omaha, Nebraska, United States, 68131-2197 |
| Methodist Estabrook Cancer Center | Omaha, Nebraska, United States, 68114 |
| Immanuel Medical Center | Omaha, Nebraska, United States, 68122 |
| Lakeside Hospital | Omaha, Nebraska, United States, 68130 |
| Alegant Health Cancer Center at Bergan Mercy Medical Center | Omaha, Nebraska, United States, 68124 |
| New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care | Concord, New Hampshire, United States, 03301 |
| New Hampshire Oncology - Hematology, PA - Hooksett | Hooksett, New Hampshire, United States, 03106 |
| Lakes Region General Hospital | Laconia, New Hampshire, United States, 03246 |
| Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton, New Jersey, United States, 08053 |
| Fox Chase Virtua Health Cancer Program at Virtua West Jersey | Voorhees, New Jersey, United States, 08043 |
| CCOP - Hematology-Oncology Associates of Central New York | East Syracuse, New York, United States, 13057 |
| Monter Cancer Center of the North Shore-LIJ Health System | Lake Success, New York, United States, 11042 |
| Don Monti Comprehensive Cancer Center at North Shore University Hospital | Manhasset, New York, United States, 11030 |
| CCOP - North Shore University Hospital | Manhasset, New York, United States, 11030 |
| Long Island Jewish Medical Center | New Hyde Park, New York, United States, 11040 |
| Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center | New York, New York, United States, 10032 |
| Stony Brook University Cancer Center | Stony Brook, New York, United States, 11794-9446 |
| Mission Hospitals - Memorial Campus | Asheville, North Carolina, United States, 28801 |
| CaroMont Cancer Center at Gaston Memorial Hospital | Gastonia, North Carolina, United States, 28053 |
| Wayne Memorial Hospital, Incorporated | Goldsboro, North Carolina, United States, 27534 |
| Pardee Memorial Hospital | Hendersonville, North Carolina, United States, 28791 |
| High Point Regional Hospital | High Point, North Carolina, United States, 27261 |
| FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center | Pinehurst, North Carolina, United States, 28374 |
| Rex Cancer Center at Rex Hospital | Raleigh, North Carolina, United States, 27607 |
| Wake Forest University Comprehensive Cancer Center | Winston-Salem, North Carolina, United States, 27157-1096 |
| Dakota Cancer Institute at Dakota Clinic - South University | Fargo, North Dakota, United States, 58103 |
| Trinity CancerCare Center | Minot, North Dakota, United States, 58701 |
| McDowell Cancer Center at Akron General Medical Center | Akron, Ohio, United States, 44307 |
| Aultman Cancer Center at Aultman Hospital | Canton, Ohio, United States, 44710-1799 |
| Clackamas Radiation Oncology Center | Clackamas, Oregon, United States, 97015 |
| Providence Milwaukie Hospital | Milwaukie, Oregon, United States, 97222 |
| Providence Newberg Medical Center | Newberg, Oregon, United States, 97132 |
| Willamette Falls Hospital | Oregon City, Oregon, United States, 97045 |
| Kaiser Permanente Health Care - Portland | Portland, Oregon, United States, 97227 |
| CCOP - Columbia River Oncology Program | Portland, Oregon, United States, 97225 |
| Providence St. Vincent Medical Center | Portland, Oregon, United States, 97225 |
| Providence Cancer Center at Providence Portland Medical Center | Portland, Oregon, United States, 97213-2967 |
| Bryn Mawr Hospital | Bryn Mawr, Pennsylvania, United States, 19010 |
| Cancer Center of Paoli Memorial Hospital | Paoli, Pennsylvania, United States, 19301-1792 |
| Albert Einstein Cancer Center | Philadelphia, Pennsylvania, United States, 19141 |
| Cancer Center at Phoenixville Hospital | Phoenixville, Pennsylvania, United States, 19460 |
| UPMC Cancer Centers | Pittsburgh, Pennsylvania, United States, 15232 |
| Chester County Hospital | West Chester, Pennsylvania, United States, 19380 |
| CCOP - Main Line Health | Wynnewood, Pennsylvania, United States, 19096 |
| Lankenau Cancer Center at Lankenau Hospital | Wynnewood, Pennsylvania, United States, 19096 |
| AnMed Cancer Center | Anderson, South Carolina, United States, 29621 |
| McLeod Regional Medical Center | Florence, South Carolina, United States, 29501 |
| CCOP - Upstate Carolina | Spartanburg, South Carolina, United States, 29303 |
| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg, South Carolina, United States, 29303 |
| Doctor's Hospital of Laredo | Laredo, Texas, United States, 78045 |
| Mountainview Medical | Berlin, Vermont, United States, 05602 |
| Fletcher Allen Health Care - University Health Center Campus | Burlington, Vermont, United States, 05401 |
| Overlake Cancer Center at Overlake Hospital Medical Center | Bellevue, Washington, United States, 98004 |
| Providence Centralia Hospital | Centralia, Washington, United States, 98531-9027 |
| Providence Regional Cancer Partnership | Everett, Washington, United States, 98201 |
| St. Francis Hospital | Federal Way, Washington, United States, 98003 |
| Providence St. Peter Hospital Regional Cancer Center | Olympia, Washington, United States, 98506-5166 |
| Good Samaritan Cancer Center | Puyallup, Washington, United States, 98372 |
| CCOP - Northwest | Tacoma, Washington, United States, 98405 |
| MultiCare Regional Cancer Center at Tacoma General Hospital | Tacoma, Washington, United States, 98405 |
| Allenmore Hospital | Tacoma, Washington, United States, 98405 |
| Franciscan Cancer Center at St. Joseph Medical Center | Tacoma, Washington, United States, 98405-3004 |
| St. Clare Hospital | Tacoma, Washington, United States, 98499 |
| Southwest Washington Medical Center Cancer Center | Vancouver, Washington, United States, 98664 |
| Marshfield Clinic Cancer Care at Regional Cancer Center | Eau Claire, Wisconsin, United States, 54701 |
| St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin, United States, 54307-3508 |
| St. Mary's Hospital Medical Center - Green Bay | Green Bay, Wisconsin, United States, 54303 |
| Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay, Wisconsin, United States, 54301-3526 |
| Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay, Wisconsin, United States, 54303 |
| Gundersen Lutheran Center for Cancer and Blood | La Crosse, Wisconsin, United States, 54601 |
| Marshfield Clinic - Marshfield Center | Marshfield, Wisconsin, United States, 54449 |
| Marshfield Clinic - Lakeland Center | Minocqua, Wisconsin, United States, 54548 |
| Green Bay Oncology, Limited - Oconto Falls | Oconto Falls, Wisconsin, United States, 54154 |
| Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay, Wisconsin, United States, 54235 |
| Marshfield Clinic - Weston Center | Weston, Wisconsin, United States, 54476 |
| Cancer Centre of Southeastern Ontario at Kingston General Hospital | Kingston, Ontario, Canada, K7L 5P9 |
| St. Catharines General Hospital at Niagara Health System | Saint Catharines, Ontario, Canada, L2R 2Z7 |
| Mount Sinai Hospital - Toronto | Toronto, Ontario, Canada, M5G 1X5 |
| Princess Margaret Hospital | Toronto, Ontario, Canada, M5G 2M9 |