Effect of Montelukast on Remodelling Markers in Asthmatic Children
Overview[ - collapse ][ - ]
Purpose | Airway smooth muscle cell layer thickening and sub epithelial fibrosis, key allergen-induced airway remodelling features not modulated by corticosteroids, are reversible by CysLT1 receptor blockade therapy in animals. No data are available, at the present, about the potential effect of LTs receptor antagonists on airway remodelling in asthmatic children. In the present study, the investigators aim to assess whether the addition of montelukast to ICS in mild asthmatic children to inhibit the release of MMP-9, TIMP-1, MMP-12, MMP-9/TIMP1 ratio, procollagen type I C-terminal peptide (PICP) and TGF-beta in the airway fluid collected by induced sputum in asthmatic children. 30-40 atopic children with mild persistent asthma. Children with asthma will be recruited and evaluated with a real life open label trial: they will be randomised into two groups at first visit (T1): 1) group A: in these patients montelukast tablets 5 mg and as needed beta agonist will be administered; 2) group B: in these patients beta agonist therapy only. All children will be evaluated after 8 weeks (T2). They will be tested for lung function, FeNO, metalloproteinase (MMP)-9, MMP-12, tissue inhibitor metalloproteinase-1 (TIMP-1), procollagen type I C-terminal peptide (PICP) and TGF-beta1 levels in sputum. |
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Condition | Asthma |
Intervention | Drug: Montelukast Drug: placebo |
Phase | Phase 4 |
Sponsor | Universita di Verona |
Responsible Party | Universita di Verona |
ClinicalTrials.gov Identifier | NCT00875082 |
First Received | April 2, 2009 |
Last Updated | June 18, 2013 |
Last verified | June 2013 |
Tracking Information[ + expand ][ + ]
First Received Date | April 2, 2009 |
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Last Updated Date | June 18, 2013 |
Start Date | February 2010 |
Estimated Primary Completion Date | April 2013 |
Current Primary Outcome Measures | FeNo, Lung Function, MMP-9, MMP-12, TIMP-1, PICP and TGFB determination [Time Frame: 8 weeks] [Designated as safety issue: No] |
Current Secondary Outcome Measures | Not Provided |
Descriptive Information[ + expand ][ + ]
Brief Title | Effect of Montelukast on Remodelling Markers in Asthmatic Children |
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Official Title | Effect of Montelukast on Metalloproteinase (MMP)-9, MMP-12, Tissue Inhibitor Metalloproteinase-1 (TIMP-1), Procollagen Type I C-terminal Peptide (PICP) and TGF-beta1 Levels in Sputum From Mild Intermittent Asthmatic Children: a Pilot Study |
Brief Summary | Airway smooth muscle cell layer thickening and sub epithelial fibrosis, key allergen-induced airway remodelling features not modulated by corticosteroids, are reversible by CysLT1 receptor blockade therapy in animals. No data are available, at the present, about the potential effect of LTs receptor antagonists on airway remodelling in asthmatic children. In the present study, the investigators aim to assess whether the addition of montelukast to ICS in mild asthmatic children to inhibit the release of MMP-9, TIMP-1, MMP-12, MMP-9/TIMP1 ratio, procollagen type I C-terminal peptide (PICP) and TGF-beta in the airway fluid collected by induced sputum in asthmatic children. 30-40 atopic children with mild persistent asthma. Children with asthma will be recruited and evaluated with a real life open label trial: they will be randomised into two groups at first visit (T1): 1) group A: in these patients montelukast tablets 5 mg and as needed beta agonist will be administered; 2) group B: in these patients beta agonist therapy only. All children will be evaluated after 8 weeks (T2). They will be tested for lung function, FeNO, metalloproteinase (MMP)-9, MMP-12, tissue inhibitor metalloproteinase-1 (TIMP-1), procollagen type I C-terminal peptide (PICP) and TGF-beta1 levels in sputum. |
Detailed Description | Not Provided |
Study Type | Interventional |
Study Phase | Phase 4 |
Study Design | Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science |
Condition | Asthma |
Intervention | Drug: Montelukast Montelukast, chewing tablets 5mg, once daily, 8 weeks Drug: placebo placebo chewing tablets once daily, plus inhaled short acting beta2 agonist as needed, 8 weeks |
Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
Recruitment Status | Completed |
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Estimated Enrollment | 30 |
Estimated Completion Date | April 2013 |
Estimated Primary Completion Date | September 2011 |
Eligibility Criteria | Inclusion Criteria: - Diagnostic criteria: the classification of asthma will be based on clinical history and examination and pulmonary function parameters, according to international guidelines. - Stage and/or severity of condition: atopic children with mild intermittent asthma will be enrolled. Atopy will be evaluated by skin-prick test to common allergens in the area. - Confirmatory physical and laboratory findings: - Age: ranging in age 6 to 14 years. - Evidence of susceptibility to the disease under study - Patients have not used ICS during 3-month period prior to study entry Exclusion Criteria: - Patients will be excluded if they had used oral steroids in the last month. - Patients will be excluded if they had acute or chronic lung diseases other than asthma, upper or lower airway infection in the previous 3 weeks or during the trial, acute asthma exacerbation, or had used oral steroids in the last month. - Patients will be excluded if they had acute or chronic lung diseases other than asthma, upper or lower airway infections in the previous 3 weeks or during the trial, acute asthma exacerbation, or had used oral steroids in the last month. |
Gender | Both |
Ages | 6 Years |
Accepts Healthy Volunteers | No |
Contacts | Not Provided |
Location Countries | Italy |
Administrative Information[ + expand ][ + ]
NCT Number | NCT00875082 |
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Other Study ID Numbers | UVAB-02 |
Has Data Monitoring Committee | No |
Information Provided By | Universita di Verona |
Study Sponsor | Universita di Verona |
Collaborators | Not Provided |
Investigators | Principal Investigator: Attilio L Boner, MD Pediatric Department, Università di Verona |
Verification Date | June 2013 |
Locations[ + expand ][ + ]
Pediatric Department, University of Verona | Verona, Italy, I-37134 |
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