The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension
Overview[ - collapse ][ - ]
Purpose | The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension. |
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Condition | Diabetes Mellitus Essential Hypertension |
Intervention | Drug: Fosinopril Drug: Metformin |
Phase | N/A |
Sponsor | China-Japan Friendship Hospital |
Responsible Party | China-Japan Friendship Hospital |
ClinicalTrials.gov Identifier | NCT01342614 |
First Received | April 26, 2011 |
Last Updated | May 11, 2011 |
Last verified | November 2005 |
Tracking Information[ + expand ][ + ]
First Received Date | April 26, 2011 |
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Last Updated Date | May 11, 2011 |
Start Date | May 2006 |
Estimated Primary Completion Date | August 2009 |
Current Primary Outcome Measures | Blood pressure measurement [Time Frame: 8 weeks] [Designated as safety issue: Yes] |
Current Secondary Outcome Measures | Not Provided |
Descriptive Information[ + expand ][ + ]
Brief Title | The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension |
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Official Title | The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension |
Brief Summary | The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension. |
Detailed Description | Not Provided |
Study Type | Interventional |
Study Phase | N/A |
Study Design | Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment |
Condition |
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Intervention | Drug: Fosinopril Fosinopril group received fosinopril, 10mg, once per day. Drug: Metformin Metformin group was treated with metformin hydrochloride, 500mg, three times per day |
Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
Recruitment Status | Completed |
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Estimated Enrollment | 140 |
Estimated Completion Date | August 2009 |
Estimated Primary Completion Date | August 2009 |
Eligibility Criteria | Inclusion Criteria: - 20 to 65 years of age, regardless of sex - duration of hypertension was <5 years - overweight or obesity, mild to moderate hypertension, receive no euglycemic agent or antiobesity drug |
Gender | Both |
Ages | 20 Years |
Accepts Healthy Volunteers | No |
Contacts | Not Provided |
Location Countries | Not Provided |
Administrative Information[ + expand ][ + ]
NCT Number | NCT01342614 |
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Other Study ID Numbers | MET140 |
Has Data Monitoring Committee | Yes |
Information Provided By | China-Japan Friendship Hospital |
Study Sponsor | China-Japan Friendship Hospital |
Collaborators | Not Provided |
Investigators | Not Provided |
Verification Date | November 2005 |