ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas
Overview[ - collapse ][ - ]
| Purpose | This is a double-blind, randomized, multicenter, phase 3 clinical trial to compare the efficacy and safety of brentuximab vedotin in combination with CHP with the standard-of-care CHOP in patients with CD30-positive mature T-cell lymphomas. |
|---|---|
| Condition | Lymphoma, Large-Cell, Anaplastic Lymphoma, Non-Hodgkin Lymphoma, T-Cell |
| Intervention | Drug: brentuximab vedotin Drug: doxorubicin Drug: prednisone Drug: vincristine Drug: cyclophosphamide |
| Phase | Phase 3 |
| Sponsor | Seattle Genetics, Inc. |
| Responsible Party | Seattle Genetics, Inc. |
| ClinicalTrials.gov Identifier | NCT01777152 |
| First Received | January 23, 2013 |
| Last Updated | March 27, 2014 |
| Last verified | March 2014 |
Tracking Information[ + expand ][ + ]
| First Received Date | January 23, 2013 |
|---|---|
| Last Updated Date | March 27, 2014 |
| Start Date | January 2013 |
| Estimated Primary Completion Date | December 2019 |
| Current Primary Outcome Measures | Progression-free survival per independent review facility (IRF) [Time Frame: Until disease progression, subsequent anticancer chemotherapy, death, or study closure, up to 5 years post-treatment] [Designated as safety issue: No] |
| Current Secondary Outcome Measures |
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Descriptive Information[ + expand ][ + ]
| Brief Title | ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas |
|---|---|
| Official Title | A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Brentuximab Vedotin and CHP (A+CHP) Versus CHOP in the Frontline Treatment of Patients With CD30-positive Mature T-cell Lymphomas |
| Brief Summary | This is a double-blind, randomized, multicenter, phase 3 clinical trial to compare the efficacy and safety of brentuximab vedotin in combination with CHP with the standard-of-care CHOP in patients with CD30-positive mature T-cell lymphomas. |
| Detailed Description | Not Provided |
| Study Type | Interventional |
| Study Phase | Phase 3 |
| Study Design | Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment |
| Condition |
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| Intervention | Drug: brentuximab vedotin 1.8 mg/kg every 3 weeks by IV infusion for 6-8 cycles Other Names: Adcetris; SGN-35Drug: doxorubicin 50 mg/m2 every 3 weeks by IV infusion for 6-8 cycles Drug: prednisone 100 mg on Days 1 to 5 of each 3-week cycle, orally for 6-8 cycles Drug: vincristine 1.4 mg/m2 (maximum 2 mg) every 3 weeks by IV infusion for 6-8 cycles Drug: cyclophosphamide 750 mg/m2 every 3 weeks by IV infusion for 6-8 cycles |
| Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
| Recruitment Status | Recruiting |
|---|---|
| Estimated Enrollment | 300 |
| Estimated Completion Date | December 2019 |
| Estimated Primary Completion Date | December 2017 |
| Eligibility Criteria | Inclusion Criteria: - Patients with newly diagnosed, CD30-positive mature T-cell lymphomas - Fluorodeoxyglucose (FDG)-avid disease by PET and measurable disease of at least 1.5 cm by CT - Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2 Exclusion Criteria: - History of another primary invasive malignancy that has not been in remission for at least 3 years - Current diagnosis of primary cutaneous CD30-positive T-cell lymphoproliferative disorders and lymphomas or mycosis fungoides - History of progressive multifocal leukoencephalopathy (PML) - Cerebral/meningeal disease related to the underlying malignancy |
| Gender | Both |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Contact: Terri Lowe 866-333-7436 clinicaltrials@seagen.com |
| Location Countries | United States, Canada, Czech Republic, Denmark, France, Israel, Italy, Korea, Republic of, Poland, Spain, Taiwan, United Kingdom |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01777152 |
|---|---|
| Other Study ID Numbers | SGN35-014 |
| Has Data Monitoring Committee | No |
| Information Provided By | Seattle Genetics, Inc. |
| Study Sponsor | Seattle Genetics, Inc. |
| Collaborators | Millennium Pharmaceuticals, Inc. |
| Investigators | Study Director: Dana Kennedy, PharmD Seattle Genetics, Inc. |
| Verification Date | March 2014 |
Locations[ + expand ][ + ]
| University of Alabama at Birmingham | Birmingham, Alabama, United States, 35294-3300 Contact: Ronda Carlisle | 205-975-2511 | rcarlisle@uab.eduPrincipal Investigator: Naresh Bellam, MD Recruiting |
|---|---|
| Stanford Cancer Center | Stanford, California, United States, 94305-5821 Contact: Sipra Choudhury | 650-736-2563 | schoudhury@stanford.eduPrincipal Investigator: Ranjana Advani, MD Recruiting |
| Yale Cancer Center | New Haven, Connecticut, United States, 06520 Contact: Stephanie Sellars | 203-737-8358 | stephanie.sellers@yale.eduPrincipal Investigator: Francine Foss, MD Recruiting |
| University of Florida Shands Cancer Center | Gainesville, Florida, United States, 32610 Contact: Cathy Spears | 352-265-0680 | cdspears@ufl.eduPrincipal Investigator: Nam H. Dang, MD Recruiting |
| MD Anderson Cancer Center Orlando | Orlando, Florida, United States, 32806 Contact: Monica Drouillard | 321-841-4347 | Monica.Drouillard@orlandohealth.comPrincipal Investigator: Jose Sarriera, M.D. Recruiting |
| University of Iowa | Iowa City, Iowa, United States, 52242 Contact: Susan Gillen | 319-467-5827 | susan-gillen@uiowa.eduPrincipal Investigator: Lori Rosenstein, M.D. Recruiting |
| University of Kansas Cancer Center | Westwood, Kansas, United States, 66205 Contact: Renee Sol | 913-588-4787 | rsol@kumc.eduPrincipal Investigator: Ruben Reyes, M.D. Recruiting |
| University of Maryland | Baltimore, Maryland, United States, 21201 Contact: Patricia Lesho | 410-328-2577 | plesho@umm.eduPrincipal Investigator: Amy Kimball, M.D. Recruiting |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States, 02215 Contact: Sangeetha Bhattar | 617-582-9723 | sangeetha_bhattar@dfci.harvard.eduPrincipal Investigator: Eric Jacobsen, MD Recruiting |
| University of Michigan Comprehensive Cancer Center | Ann Arbor, Michigan, United States, 48109 Contact: Erica Chapman | 734-232-0716 | echapman@med.umich.eduPrincipal Investigator: Mark Kaminski, M.D. Recruiting |
| Park Nicollet Institute | St. Louis Park, Minnesota, United States, 55426 Contact: Laura Maybon | 952-993-5710 | Laura.Maybon@parknicollet.comPrincipal Investigator: Kendra Kubiak, MD Recruiting |
| Washington University School of Medicine | St. Louis, Missouri, United States, 63110 Contact: Courtney L. Darkow | 314-362-4206 | cdarkow@dom.wustl.eduPrincipal Investigator: Nancy Bartlett, MD Recruiting |
| Hackensack University Medical Center | Hackensack, New Jersey, United States, 07601 Contact: Kelly A. Azzollini | 551-996-3277 | kazzollini@hackensackumc.orgPrincipal Investigator: Tatyana Feldman, MD Recruiting |
| Montefiore Medical Center/Albert Einstein College of Medicine | Bronx, New York, United States, 10467 Contact: Lawrence Almanzar | 718-920-6642 | lalmanza@montefiore.orgPrincipal Investigator: Stefan Barta, M.D. Recruiting |
| Memorial Sloan Kettering Cancer Center | New York, New York, United States, 10021 Contact: Kurt Bantilan | 646-449-1308 | bantilak@mskcc.orgPrincipal Investigator: Steven Horwitz, MD Recruiting |
| Weill Cornell Medical College | New York, New York, United States, 10021 Contact: Jonathan Navi | 212-746-1858 | jon3001@med.cornell.eduPrincipal Investigator: Jia Ruan, MD, PhD Recruiting |
| Columbia University Medical Center | New York, New York, United States, 10019 Contact: Ameet Narwal | 212-326-5732 | an2284@cumc.columbia.eduPrincipal Investigator: Owen A. O'Connor, M.D.; PhD Recruiting |
| University of Rochester Medical Center | Rochester, New York, United States, 14642 Contact: Michael Brady | 585-275-5825 | Michael_Brady@urmc.rochester.eduPrincipal Investigator: Jonathan Friedberg, MD Recruiting |
| Jewish Hospital, The | Cincinnati, Ohio, United States, 45236 Contact: Chris Hensley | 513-686-3385 | mchensley@health-partners.orgPrincipal Investigator: Miguel Islas-Ohlmayer, MD Recruiting |
| Cleveland Clinic, The | Cleveland, Ohio, United States, 44195 Contact: Elizabeth Gazdick | 216-445-8907 | gazdice@ccf.orgPrincipal Investigator: Deepa Jagadeesh, M.D. Recruiting |
| James Cancer Hospital / Ohio State University | Columbus, Ohio, United States, 43210 Contact: Michelle Messer | 614-366-4470 | Michelle.Messer@osumc.eduPrincipal Investigator: Pierluigi Porcu, M.D. Recruiting |
| Mercy Clinic Oklahoma Communities | Oklahoma City, Oklahoma, United States, 73120 Contact: Paige Chiles | 405-752-3531 | paige.chiles@mercy.netPrincipal Investigator: James Hampton, M.D. Recruiting |
| Thomas Jefferson University | Philadelphia, Pennsylvania, United States, 19107 Contact: Jennifer Cloud | 215-955-5769 | Jennifer.Cloud@jefferson.eduPrincipal Investigator: Barbara Pro, MD Recruiting |
| Sarah Cannon Research Institute | Nashville, Tennessee, United States, 37203 Contact: Wanda Smith | wanda.smith@scresearch.netPrincipal Investigator: Ian Flinn, M.D. Recruiting |
| Charles A. Sammons Cancer Center | Dallas, Texas, United States, 75246 Contact: Erica Goetz | 214-818-8325 | erica.goetz@baylorhealth.eduPrincipal Investigator: Estil Vance, M.D. Recruiting |
| MD Anderson Cancer Center /The University of Texas | Houston, Texas, United States, 77030-4000 Contact: Forlisa Nauling | 713-792-0240 | fnauling@mdanderson.orgPrincipal Investigator: Michelle Fanale, MD Recruiting |
| University of Virginia | Charlottesville, Virginia, United States, 22908-0716 Contact: Kimberly M. Underwood | 434-982-3947 | km3q@virginia.eduPrincipal Investigator: Michael Douvas, MD Recruiting |
| Virginia Commonwealth University Medical Center | Richmond, Virginia, United States, 23298 Contact: Kathy (Kathryn) Candler | 804-828-4732 | kcandler@vcu.eduPrincipal Investigator: John McCarty, MD Recruiting |
| Virginia Mason Medical Center | Seattle, Washington, United States, 98101 Contact: Leila C. Ponce | 206-342-6926 | Leila.Ponce@vmmc.orgPrincipal Investigator: David Aboulafia, M.D. Recruiting |
| Seattle Cancer Care Alliance / University of Washington Medical Center | Seattle, Washington, United States, 98109 Contact: Leslie Braley | 206-288-6854 | lbraley@seattlecca.orgPrincipal Investigator: Andrei Shustov, MD Recruiting |
| University of Alberta/Cross Cancer Institute | Edmonton, Alberta, Canada, T6G1Z2 Contact: Lindzie Toshack | 780-577-8135 | lindzie.toshack@albertahealthservices.caPrincipal Investigator: Neil Chua, M.D. Recruiting |
| British Columbia Cancer Agency - Vancouver Centre | Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Elena Moon | 604-877-6000 | emoon@bccancer.bc.caPrincipal Investigator: Kerry Savage, M.D. Recruiting |
| McGill University Department of Oncology / McGill University Health Centre | Montreal, Quebec, Canada, H3H 2R9 Contact: Penny Chipman | 514-398-1444 | penny.chipman@mcgill.caPrincipal Investigator: Kelly Davison Recruiting |
| Fakultni nemocnice Brno | Brno, Czech Republic, 625 00 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Jiri Mayer, M.D. Recruiting |
| Fakultni nemocnice Hradec Kralove | Hradec Kralove, Czech Republic, 500 05 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: David Belada, M.D. Recruiting |
| Fakultni Nemocnice Kralovske Vinohrady | Praha 10, Czech Republic, 100 34 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Heidi Móciková, M.D. Recruiting |
| Vseobecna fakultni nemocnice v Praze | Praha 2, Czech Republic, 128 08 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Marek Trneny Recruiting |
| Arhus University Hospital | Arhus, Denmark, DK-8000 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Francesco d'Amore, MD Recruiting |
| Rigshospitalet | Copenhagen, Denmark, 2100 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Peter de Nully Brown, M.D. Recruiting |
| Odense University Hospital | Odense C, Denmark, 5000 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Jacob Haaber Christensensen, M.D. Recruiting |
| Roskilde Sygehus | Roskilde, Denmark, 4000 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Claudia Schöllkopf, M.D. Recruiting |
| Groupe Hospitalier du Haut Leveque | Pessac, Aquitaine, France, 33604 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Kamal Krimo Bouabdallah, M.D. Recruiting |
| Hopital Saint-Louis/Service d'Hematologie | Paris, Cedex 10, France, 75475 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Pauline Brice, M.D. Recruiting |
| Hôpital Dupuytren | Limoges, Limousin, France, 87042 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Dominique Bordessoule, M.D. Recruiting |
| CHRU de Lille | Lille cedex, Nord Pas-de-calais, France, 59037 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Franck Morschhauser, M.D. Recruiting |
| Hopital Henri Mondor | Creteil, France, 94010 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Corinne Haioun Recruiting |
| CHU Nantes - Hopital Hotel Dieu | Nantes, France, 44093 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Steven Le Gouill, MD Recruiting |
| Groupe Hospitalier Pitié-Salpétrière | Paris, France, 75013 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Sylvain Choquet, M.D. Recruiting |
| Centre Hospitalier Lyon Sud | Pierre Benite, France, 69310 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Gilles Salles, MD Recruiting |
| Centre Hospitalier Universitaire de Poitiers | Poitiers, France, 86000 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Vincent Delwail, M.D. Recruiting |
| Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou | Rennes, France, 35033 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Sophie De Guibert, M.D. Recruiting |
| Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer | Rouen, France, 76038 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Herve Tilly, MD, PhD Recruiting |
| Soroka Medical Center, Dept. of Oncology | Beer Sheva, Beersheva, Israel, 84101 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Itai Levi, M.D. Recruiting |
| Rambam Health Corp. | Haifa, Israel, 31096 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Netanel Horowitz, M.D. Recruiting |
| Hadassah Ein-Kerem Medical Centre | Jerusalem, Israel, 91120 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Dina Ben Yehuda, M.D. Recruiting |
| Rabin Medical Center | Petach Tikva, Israel, 49414 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Ronit Gurion, M.D. Recruiting |
| Tel Aviv Sourasky Medical Center | Tel Aviv, Israel, 64239 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Ilya Kirgner, M.D. Recruiting |
| Ospedali Riuniti Marche Nord - Presidio San Salvatore | Pesaro, Pesaro E Urbino, Italy, 61100 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Giuseppe Visani, M.D. Recruiting |
| Azienda Ospedaliera Papa Giovanni XXIII | Bergamo, Italy, 24128 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Alessandro Rambaldi, M.D. Recruiting |
| Azienda Ospedaliera Spedali Civili di Brescia | Brescia, Italy, 25123 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Giuseppe Rossi, M.D. Recruiting |
| Azienda Ospedaliera-Universitaria Vittorio Emanuele-Ferrarotto-Santo Bambino | Catania, Italy, 95124 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Francesco di Raimondo, M.D. Recruiting |
| Azienda Ospedaliera Universitaria San Martino | Genova, Italy, 16132 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Angelo Carella, M.D. Recruiting |
| Ospedala Niguarda Ca'Granda | Milano, Italy, 20162 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Enrica Morra Recruiting |
| Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico | Milano, Italy, 20122 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Luca Baldini, M.D. Recruiting |
| IRCSS Policlinico San Matteo | Pavia, Italy, 27100 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Luca Arcaini, M.D. Recruiting |
| Istituto Clinico Humanitas | Rozzano, Italy, 20089 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Armando Santoro, M.D. Recruiting |
| Azienda Ospedaliera S. Giovanni Battista Molinette | Torino, Italy, 10126 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Umberto Vitolo Recruiting |
| Azienda Ospedaliera Universitaria Integrata di Verona | Verona, Italy, 37126 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Fabio Benedetti, M.D. Recruiting |
| Seoul National University Bundang Hospital | Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-707 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Jong-Seok Lee, M.D. Recruiting |
| Chonnam National University Hwasun Hospital | Hwasun, Jeollanam-do, Korea, Republic of, 519-763 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Je-Jung Lee, M.D. Recruiting |
| Keimyung University Dongsan Medical Center | Daegu, Korea, Republic of, 700-712 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Young Rok DO, M.D. Recruiting |
| Severance Hospital, Yonsei University Health System | Seoul, Korea, Republic of, 120-752 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: June-Won Cheong, M.D. Recruiting |
| Seoul National University Hospital | Seoul, Korea, Republic of, 110-744 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Sung-Soo Yoon, M.D. Recruiting |
| Asan Medical Center | Seoul, Korea, Republic of, 138-736 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Cheolwon Suh, M.D. Recruiting |
| Seoul Saint Mary's Hospital | Seoul, Korea, Republic of, 137-701 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Seok-Goo Cho, M.D. Recruiting |
| Samsung Medical Center | Seoul, Korea, Republic of, 135-710 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Won Seog Kim, M.D. Recruiting |
| Malopolskie Centrum Medyczne S.C. | Kraków, Malopolskie, Poland, 30-510 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Wojciech Jurczak, M.D. Recruiting |
| Szpital Specjalistyczny w Brzozowie | Brzozow, Podkarpackie, Poland, 36-200 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Andrzej Pluta, M.D. Recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespól Szpitali Miejskich | Chorzów, Slaskie, Poland, 41-500 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Sebastian Grosicki, M.D. Recruiting |
| Oddzial Transplantacji Szpiku Centrum Onkologii- Instytut M. Sklodowskiej-Curie, Oddzial Gliwicach | Gliwice, Poland, 44-101 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Jerzy Holowiecki, M.D. Recruiting |
| Centrum Onkologii Institut im. Marii Sklodowskiej-Curie | Warsaw, Poland, 02-781 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Jan Walewski, M.D. Recruiting |
| Institut Català D'oncologia | L'Hospitalet de Llobregat, Barcelona, Spain, 08907 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Eva Domingo, M.D. Recruiting |
| Hospital Puerta de Hierro Majadahonda | Majadahonda, Madrid, Spain, 28222 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Jose Garcia-Marco, M.D. Recruiting |
| Hospital de la Santa Creu i Sant Paul | Barcelona, Spain, 08025 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Javier Briones, M.D. Recruiting |
| Hospital de León | Leon, Spain, 24071 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Silvia Fernández Ferrero, M.D. Recruiting |
| Hospital Universitario La Paz | Madrid, Spain, 28046 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Miguel Canales, M.D. Recruiting |
| Hospital Universitari i Politècnic La Fe | Valencia, Spain, 46026 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: José Gomez Codina, M.D. Recruiting |
| National Cheng Kung University Hospital | Tainan, Tainan City, Taiwan, 70403 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Tsai-Yun Chen, M.D. Recruiting |
| Chang Gung Memorial Hospital, Kaohsiung | Kaohsiung, Taiwan, 83301 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Ching-Yuan Kuo, M.D. Recruiting |
| China Medical University Hospital | Taichung, Taiwan, 404 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Su-Peng Yeh, M.D. Recruiting |
| Chang Gung Memorial Hospital | Taoyuan, Taiwan, 33305 Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Hung Chang, M.D. Recruiting |
| Freeman Hospital | Newcastle upon Tyne, England, United Kingdom, NE7 7DN Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Anne Lennard, M.D. Recruiting |
| Nottingham University Hospitals NHS Trust | Nottingham, England, United Kingdom, NG5 1PD Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Christopher Fox, M.D. Recruiting |
| University Hospitals of Leicester NHS Trust | Leicester, United Kingdom, LE1 9HN Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Martin Dyer Recruiting |
| Christie Hospital NHS Foundation Trust, The | Manchester, United Kingdom, M20 4BX Contact: Terri Lowe | 866-333-7436 | clinicaltrials@seagen.comPrincipal Investigator: Tim Illidge, M.D. Recruiting |