Drug Discrimination in Methadone-Maintained Humans Study 1
Overview[ - collapse ][ - ]
Purpose | This study involves giving psychoactive drugs intramuscularly (injected into the muscle of the upper arm or the hip) and/or orally, and measuring the subject's ability to tell the difference between one drug and another, as well as measuring the effects of the drugs on mood, physiology (e.g., heart rate, blood pressure, respiration rate) and behavior. Each subject will receive 2-4 of the listed interventions. |
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Condition | Drug Dependence |
Intervention | Drug: Cycloserine Drug: Diltiazem Drug: Gabapentin Drug: Isradipine Drug: Naloxone Drug: Nifedipine Drug: Placebo Device: Saline Drug: Verapamil |
Phase | Phase 1 |
Sponsor | University of Arkansas |
Responsible Party | University of Arkansas |
ClinicalTrials.gov Identifier | NCT00593463 |
First Received | January 4, 2008 |
Last Updated | March 10, 2011 |
Last verified | March 2011 |
Tracking Information[ + expand ][ + ]
First Received Date | January 4, 2008 |
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Last Updated Date | March 10, 2011 |
Start Date | September 2006 |
Estimated Primary Completion Date | May 2010 |
Current Primary Outcome Measures | Drug Discrimination Measure [Time Frame: Every session] [Designated as safety issue: No] |
Current Secondary Outcome Measures |
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Descriptive Information[ + expand ][ + ]
Brief Title | Drug Discrimination in Methadone-Maintained Humans Study 1 |
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Official Title | Drug Discrimination in Methadone-Maintained Humans Study 1 |
Brief Summary | This study involves giving psychoactive drugs intramuscularly (injected into the muscle of the upper arm or the hip) and/or orally, and measuring the subject's ability to tell the difference between one drug and another, as well as measuring the effects of the drugs on mood, physiology (e.g., heart rate, blood pressure, respiration rate) and behavior. Each subject will receive 2-4 of the listed interventions. |
Detailed Description | Not Provided |
Study Type | Interventional |
Study Phase | Phase 1 |
Study Design | Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator) |
Condition | Drug Dependence |
Intervention | Drug: Cycloserine Cycloserine: 500, 675, 750 mg oral capsule may possibly be given Other Names:
Diltiazem: 30, 60, 120 mg oral capsule may possibly be Other Names: CardizemDrug: Gabapentin Gabapentin: 100, 200, 400 mg oral capsule may possibly be given Other Names: NeurontinDrug: Isradipine Isradipine: 5, 10 mg oral capsule may possibly be given Other Names: DynaCircDrug: Naloxone Naloxone: 0.15 mg/70 kg or 0.2 mg I.M. injection may possibly be given Other Names: NarcaDrug: Nifedipine Nifedipine: 5, 10, 20 mg oral capsule may possibly be given Other Names:
Placebo (sugar pill or microcrystalline cellulose): oral capsule may possibly be given Device: Saline Saline: I.M. injection may possibly be given Drug: Verapamil Verapamil: 30, 60, 120 mg oral capsule may possibly be given Other Names: Veralan |
Study Arm (s) | Experimental: 1 Receives 2-4 of the interventions listed |
Recruitment Information[ + expand ][ + ]
Recruitment Status | Completed |
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Estimated Enrollment | 40 |
Estimated Completion Date | May 2010 |
Estimated Primary Completion Date | May 2010 |
Eligibility Criteria | Inclusion Criteria: 1. Must be between the ages of 18-65. 2. Participation in the UAMS Substance Abuse Treatment Clinic Methadone Maintenance Program or the CATAR Clinic Little Rock with maintenance on a stable dose of methadone (+ or - 10 mg) for at least 1 month prior to study entry. 3. Subjects would have to be in "good standing" in the methadone maintenance program in order to participate; i.e., compliance with scheduled medication and group therapy session hours. This would be defined as < 3 missed methadone medications and missed < 3 group or <3 individual therapy sessions in the two months prior to study participation 4. Subjects must submit a urine sample negative for illicit drugs prior to study entry. 5. Subjects must be able to read and understand English. Exclusion Criteria: Exclusion criteria 1. Ill health (major cardiovascular, renal, endocrine, hepatic disorder, to be determined by history provided by the prospective subject or laboratory evaluation as outlined below). 2. Current diagnosis of other drug or alcohol physical dependence (other than tobacco). 3. History of major psychiatric disorder (psychosis, schizophrenia, bipolar, depression) 4. Pregnancy, plans to become pregnant or inadequate birth control. 5. Present or recent use of over-the-counter psychoactive drug, prescription psychoactive drug or drug that would have major interaction with drugs to be tested. 6. History of severe reaction to Narcan challenge, which may have been given as part of admission into the Methadone Maintenance Program or to reverse overdose. 7. Liver function tests greater than 3 times normal, BUN and Creatinine outside normal range, or thyroid function tests outside normal range. 8. EKG abnormalities including but not limited to: bradycardia (<60 bpm); prolonged with QTc interval (>420 msec); Wolff-Parkinson White syndrome; wide complex tachycardia; 2nd degree, Mobitz type II heart block; 3rd degree heart block; left or right bundle branch block. |
Gender | Both |
Ages | 18 Years |
Accepts Healthy Volunteers | No |
Contacts | Not Provided |
Location Countries | United States |
Administrative Information[ + expand ][ + ]
NCT Number | NCT00593463 |
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Other Study ID Numbers | R01-DA010017-01 |
Has Data Monitoring Committee | Yes |
Information Provided By | University of Arkansas |
Study Sponsor | University of Arkansas |
Collaborators | Not Provided |
Investigators | Principal Investigator: Alison Oliveto, PhD University of Arkansas |
Verification Date | March 2011 |
Locations[ + expand ][ + ]
University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States, 72205 |
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