Comparison of Blood Pressure Medications on Metabolism
Overview[ - collapse ][ - ]
Purpose | The purpose of this study is to determine if there are differences, (benefits) between carvedilol and metoprolol in the treatment of HTN in patients with type 2 diabetes. Specifically we will be looking at differences in blood pressure and blood sugar control, endothelial function, inflammation, oxidative stress and coagulation. Subjects will be randomized to one of the two beta-blockers and followed for 5 months. Each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, Inflammatory and oxidative stress markers will be measured. Endothelial function will be measured using brachial artery ultrasound and laser skin Doppler |
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Condition | Diabetes |
Intervention | Drug: carvedilol Drug: metoprolol |
Phase | Phase 4 |
Sponsor | University of New Mexico |
Responsible Party | University of New Mexico |
ClinicalTrials.gov Identifier | NCT00642434 |
First Received | March 21, 2008 |
Last Updated | August 24, 2011 |
Last verified | August 2011 |
Tracking Information[ + expand ][ + ]
First Received Date | March 21, 2008 |
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Last Updated Date | August 24, 2011 |
Start Date | January 2004 |
Estimated Primary Completion Date | July 2008 |
Current Primary Outcome Measures | change in endothelial function [Time Frame: 5 months] [Designated as safety issue: No] |
Current Secondary Outcome Measures | Not Provided |
Descriptive Information[ + expand ][ + ]
Brief Title | Comparison of Blood Pressure Medications on Metabolism |
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Official Title | Carvedilol vs.Metoprolol: A Comparison of Effects on Endothelial Function and Oxidative Stress in Response to Acute Hyperglycemia in Patients With Type 2 Diabetes and Hypertension |
Brief Summary | The purpose of this study is to determine if there are differences, (benefits) between carvedilol and metoprolol in the treatment of HTN in patients with type 2 diabetes. Specifically we will be looking at differences in blood pressure and blood sugar control, endothelial function, inflammation, oxidative stress and coagulation. Subjects will be randomized to one of the two beta-blockers and followed for 5 months. Each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, Inflammatory and oxidative stress markers will be measured. Endothelial function will be measured using brachial artery ultrasound and laser skin Doppler |
Detailed Description | Not Provided |
Study Type | Interventional |
Study Phase | Phase 4 |
Study Design | Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Diagnostic |
Condition | Diabetes |
Intervention | Drug: carvedilol variable Drug: metoprolol variable |
Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
Recruitment Status | Completed |
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Estimated Enrollment | 21 |
Estimated Completion Date | July 2008 |
Estimated Primary Completion Date | June 2008 |
Eligibility Criteria | Inclusion Criteria: - not enrolling Exclusion Criteria: - not enrolling |
Gender | Both |
Ages | 45 Years |
Accepts Healthy Volunteers | No |
Contacts | Not Provided |
Location Countries | United States |
Administrative Information[ + expand ][ + ]
NCT Number | NCT00642434 |
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Other Study ID Numbers | UNM04094 |
Has Data Monitoring Committee | Yes |
Information Provided By | University of New Mexico |
Study Sponsor | University of New Mexico |
Collaborators | Not Provided |
Investigators | Not Provided |
Verification Date | August 2011 |
Locations[ + expand ][ + ]
UNMHSC | Albquerque, New Mexico, United States, 87131 |
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