Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia | RxWiki

Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia

Overview[ - collapse ][ - ]

Purpose	Schizophrenia patients treated with clozapine have a high prevalence of obesity-related metabolic syndrome. The condition is often poorly treated and may lead to the emergence of coronary heart disease and type 2 diabetes. The study will investigate whether structured treatment provided at the site of the outpatient psychiatric clinic of metabolic syndrome in this population will decrease the severity of metabolic syndrome as compared with usual care received by these patients in the community.
Condition	Metabolic Syndrome
Intervention	Drug: Pravastatin, Fenofibrate, Metformin, Orlistat, irbesartan Other: As selected by community physician
Phase	N/A
Sponsor	North Shore Long Island Jewish Health System
Responsible Party	North Shore Long Island Jewish Health System
ClinicalTrials.gov Identifier	NCT00794963
First Received	November 19, 2008
Last Updated	November 17, 2011
Last verified	November 2011

Tracking Information[ + expand ][ + ]

First Received Date	November 19, 2008
Last Updated Date	November 17, 2011
Start Date	November 2008
Estimated Primary Completion Date	May 2010
Current Primary Outcome Measures	Change in Weight [Time Frame: baseline and 8 months] [Designated as safety issue: No]
Current Secondary Outcome Measures	Not Provided

Descriptive Information[ + expand ][ + ]

Brief Title	Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia
Official Title	Aggressive Treatment of Metabolic Syndrome in Patients Treated With Clozapine for Schizophrenia
Brief Summary	Schizophrenia patients treated with clozapine have a high prevalence of obesity-related metabolic syndrome. The condition is often poorly treated and may lead to the emergence of coronary heart disease and type 2 diabetes. The study will investigate whether structured treatment provided at the site of the outpatient psychiatric clinic of metabolic syndrome in this population will decrease the severity of metabolic syndrome as compared with usual care received by these patients in the community.
Detailed Description	Background Compared with the general population, patients with schizophrenia have an increased risk of death from atherosclerotic cardiovascular diseases (ASCVD) that reflect coronary heart disease, stroke and peripheral vascular disease (Newcomer, 2007). Among the factors contributing to the increased prevalence of ASCVD in schizophrenia are a) unhealthy lifestyle (cigarette smoking, lack of physical activity, increased consumption of calorie-dense foods rich in saturated fats and carbohydrates), b) genetic vulnerability to glucose intolerance and diabetes; c) metabolic side-effects of psychotropic drugs; and d) lack of access or compliance with community-based medical care, particularly clozapine or olanzapine. Biologically, the common pathway leading to increased risk of ASCVD in schizophrenia is the metabolic syndrome, an entity defined as 3 or more of the following 5 characteristics: abdominal obesity, increased blood pressure, increased fasting glucose, increased levels of triglycerides and abnormally low levels of high-density lipoprotein cholesterol. The prevalence of metabolic syndrome in schizophrenia ranges form 29% to 63% and is significantly greater than the frequency of 21% in the general population (Correll et al., 2006). As in the general population, the metabolic syndrome of patients with schizophrenia is explained by increased intraabdominal adiposity leading to insulin resistance and excess of circulating free fatty acids which are converted into triglyceride-rich lipoproteins with atherogenic potential. The treatment of metabolic syndrome relies primarily on therapeutic lifestyle changes aiming to reduce weight, decrease intake of saturated fats and carbohydrates with high glycemic index, eliminate smoking, and increase physical activity. Drug therapy is required for the patients who fail to respond to lifestyle changes and the American Heart Association (AHA) has published detailed guidelines for the pharmacologic management of metabolic syndrome (Grundy et al., 2005). These guidelines are based on research indicating substantial improvement in the risk of ASCVD of patients with metabolic syndrome treated with metformin and acarbose for impaired glucose tolerance; statins, fibrates and nicotinic acid for lipid abnormalities; angiotensin receptor blockers for increased blood pressure; and sibutramine and orlistat for weight management. Some of these interventions (e.g., metformin and sibutramine for weight management) have been completed in research settings with small samples of patients with schizophrenia (Henderson et al., 2005; Wu et al., 2008) and have produced promising results. However, treatment trials using the comprehensive AHA guidelines have not yet been conducted in schizophrenics with metabolic syndrome. Current Standard of Care at Zucker Hillside Hospital The Aftercare Clinic at Zucker Hillside Hospital has the oldest Clozapine Clinic in the U.S. Opened in 1987, the Clozapine Clinic has a current enrollment of 230 adult patients. According to hospital policy, all Clozapine Clinic patients must have an annual physical evaluation and laboratory tests for the detection of obesity, dyslipidemia, glucose intolerance, hypertension and metabolic syndrome. The mandatory physical examinations are performed by each patient's outside physician or by the Clinic's Nurse Practitioners. Laboratory testing is performed at Long Island Jewish Medical Center's laboratories. The physical examinations and laboratory findings are reviewed by each patient's psychiatrists. Patients with physical or laboratory abnormalities are referred for care to internal medicine specialists (i.e., general internal medicine, endocrinology, cardiology) in private practice or to the appropriate outpatient clinics at Long Island Jewish Medical Center as deemed necessary by their psychiatrists. At the present time, it is not known how many schizophrenia patients with metabolic syndrome treated in the Aftercare Program (outpatient clinic) at ZHH receive care according to the standard defined by the American Heart Association. Objective We plan to evaluate the effect of application of AHA guidelines for the treatment of metabolic syndrome in patients with schizophrenia who are receiving clozapine, an antipsychotic known to produce weight gain and metabolic abnormalities in a majority of patients (Newcomer, 2006). The study will include only outpatients receiving care in the Clozapine Clinic. . The study's primary aim is to compare the effectiveness of managing metabolic syndrome in schizophrenia at the site of psychiatric outpatient services (integrated care) with treatment obtained and coordinated by the patients Hillside psychiatrist (usual care). We propose that Integrated care will remove access barriers, improve compliance, enhance communication between psychiatry and internal medicine providers, and facilitate education for weight management and smoking cessation. The management of metabolic syndrome for patients receiving integrated care will adhere to the AHA guidelines (Grundy et al., 2005) which describe dietary, exercise and pharmacologic interventions that have been extensively validated in the general population. All of the medications suggested in the guidelines have been FDA-approved for the individual components of metabolic syndrome. The 'usual care' group will receive the current standard of care set by Hillside Hospital. Importance of the Study This is the first randomized trial of a "no-barriers" model of medical care for an underserved and vulnerable mentally ill population. To increase homogeneity of the study population and significance of the expected difference between integrated and usual care, the study will assess only patients with the same psychiatric diagnosis (schizophrenia), treated with the same psychotropic (clozapine) in a single, well-established outpatient setting. The duration of the study is adequate to demonstrate whether the metabolic syndrome components respond to life style modification and /or specific pharmacological intervention. Research Design and Methods Hypothesis Integrated, on-site, medical management of metabolic syndrome in patients with schizophrenia is superior to usual care in the community, primarily because it will remove barriers related to access to medical providers and increase compliance with drug therapy and laboratory testing. The improvement will lead to decreased frequency of metabolic syndrome in the sample, decreased risk of future ASCVD events (as predicted by AHA-recommended instruments), decreased waist circumference, fasting glucose, blood pressure and triglyceride levels and increased levels of HDL.
Study Type	Interventional
Study Phase	N/A
Study Design	Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Condition	Metabolic Syndrome
Intervention	Drug: Pravastatin, Fenofibrate, Metformin, Orlistat, irbesartan The intervention in the 4 patients consisted in dietary recommendations, advice regarding increasing physical activity, and use of Orlistat 60 mg three times daily. No other drugs were prescribed. Other: As selected by community physician As selected by community physician
Study Arm (s)	Experimental: Integrated care Provide on-site internal medicine evaluation, treatment and follow up of metabolic syndrome for patients in Clozapine Clinic No Intervention: Usual Care Follow the 8-month outcome of schizophrenia patients with metabolic syndrome treated in the community

Recruitment Information[ + expand ][ + ]

Recruitment Status	Terminated
Estimated Enrollment	8
Estimated Completion Date	May 2010
Estimated Primary Completion Date	May 2010
Eligibility Criteria	Inclusion Criteria: - patients with schizophrenia treated with clozapine; age 19-79 Exclusion Criteria: - pregnant women, personal history of/or comorbid eating disorders
Gender	Both
Ages	19 Years
Accepts Healthy Volunteers	No
Contacts	Not Provided
Location Countries	United States

Administrative Information[ + expand ][ + ]

NCT Number	NCT00794963
Other Study ID Numbers	08-177
Has Data Monitoring Committee	No
Information Provided By	North Shore Long Island Jewish Health System
Study Sponsor	North Shore Long Island Jewish Health System
Collaborators	Not Provided
Investigators	Not Provided
Verification Date	November 2011

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