Adjuvant Therapy for High-Risk Breast Cancer With Wkly Adriamycin & Oral Cytoxan With G-CSF for 12 Wks; Wkly Taxol x 12 | RxWiki

Adjuvant Therapy for High-Risk Breast Cancer With Wkly Adriamycin & Oral Cytoxan With G-CSF for 12 Wks; Wkly Taxol x 12

Overview[ - collapse ][ - ]

Purpose	The primary objectives of the study are to evaluate the feasibility and toxicity of treatment with 12 weeks of Adriamycin with daily oral Cytoxan with G-CSF support followed by 12 weeks of Taxol. Feasibility will be assessed by comparing the delivered dose intensity of each drug to the delivered dose intensity in previous trials. Toxicity will be assessed by comparing the incidence and severity of toxicity with these drugs to previous trials using these drugs in the same combination. We hypothesize metronomic, dose dense treatment as given in this study will be less toxic and more effective than historical regimens using the same drugs in a less metronomic, dose dense manner.
Condition	Breast Neoplasm
Intervention	Drug: Paclitaxel Drug: Doxorubicin Drug: Cyclophosphamide Drug: G-CSF
Phase	Phase 2
Sponsor	University of Washington
Responsible Party	University of Washington
ClinicalTrials.gov Identifier	NCT00194753
First Received	September 14, 2005
Last Updated	September 12, 2012
Last verified	September 2012

Tracking Information[ + expand ][ + ]

First Received Date	September 14, 2005
Last Updated Date	September 12, 2012
Start Date	December 2001
Estimated Primary Completion Date	March 2011
Current Primary Outcome Measures	Delivered dose intensity [Time Frame: 24 weeks] [Designated as safety issue: No] Toxicity [Time Frame: 24 weeks] [Designated as safety issue: Yes]
Current Secondary Outcome Measures	Time to treatment failure [Time Frame: 7 years] [Designated as safety issue: No] Overall survival [Time Frame: 7 years] [Designated as safety issue: No]

Descriptive Information[ + expand ][ + ]

Brief Title	Adjuvant Therapy for High-Risk Breast Cancer With Wkly Adriamycin & Oral Cytoxan With G-CSF for 12 Wks; Wkly Taxol x 12
Official Title	Adjuvant Therapy for High-Risk Localized Breast Cancer With Weekly Adriamycin +/- Oral Cytoxan With Continuous G-CSF Support for 12 Weeks Followed by Weekly Taxol for 12 Weeks, Phase II
Brief Summary	The primary objectives of the study are to evaluate the feasibility and toxicity of treatment with 12 weeks of Adriamycin with daily oral Cytoxan with G-CSF support followed by 12 weeks of Taxol. Feasibility will be assessed by comparing the delivered dose intensity of each drug to the delivered dose intensity in previous trials. Toxicity will be assessed by comparing the incidence and severity of toxicity with these drugs to previous trials using these drugs in the same combination. We hypothesize metronomic, dose dense treatment as given in this study will be less toxic and more effective than historical regimens using the same drugs in a less metronomic, dose dense manner.
Detailed Description	The systemic cancer treatments used in this study (Adriamycin, Cytoxan and Taxol) are all delivered in a dose dense, metronomic manner (weekly or daily). It is our hypothesis that dose dense treatment will result in optimum delivered dose intensity while minimizing toxicity. We will test these hypotheses by comparing the delivered dose intensity of the drugs to the delivered dose intensity of standard regimens. We will also compare time to relapse, survival and toxicity of this treatment to historic, standard regimens.
Study Type	Interventional
Study Phase	Phase 2
Study Design	Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Condition	Breast Neoplasm
Intervention	Drug: Paclitaxel 80 mg/m2 IV for 12 weeks following completion of doxorubicin and cyclophosphamide Drug: Doxorubicin 24 mg/m2 IV weekly x 12 Drug: Cyclophosphamide 60 mg/m2 PO daily for 12 weeks Drug: G-CSF 5 mcg per kg subcutaneously days 2 - 7 during doxorubicin and cyclophosphamide for 12 weeks
Study Arm (s)	Experimental: 1 Weekly doxorubicin (24 mg/m2 IV) with daily oral cyclophosphamide (60 mg/m2 PO) for 12 weeks with G-CSF support days 2 - 7 of each week followed by weekly paclitaxel (80 mg/m2 IV) for 12 weeks.

Recruitment Information[ + expand ][ + ]

Recruitment Status	Completed
Estimated Enrollment	80
Estimated Completion Date	March 2011
Estimated Primary Completion Date	March 2011
Eligibility Criteria	Inclusion Criteria: - Patient must have a histologically confirmed diagnosis of primary breast carcinoma that has been surgically resected. (This regimen is not intended for neoadjuvant treatment.) - The attending physician must judge the patient to be an appropriate candidate for Adriamycin based adjuvant chemotherapy. Appropriate candidates generally include those with stage II or III breast cancer. The individual attending physician, however, should make the decision. - Tumor HER-2/neu expression must be determined prior to study enrollment. Assessment may be by fluorescence in situ hybridization (FISH) assay or by immunocytochemistry (ICC). If determination is "intermediate" by immunocytochemistry, FISH must be performed. Protocol therapy is determined by HER-2/neu result. - Patient must be at least 18. - The patient must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines. - Pre-study hematologic values required for entry onto trial are: WBC greater than= 4,000/mm3, ANC greater than= 1,500/mm3 and platelets greater than= 100,000/mm3. Exclusion Criteria: - Patients with significant renal dysfunction (creatinine greater than 1.5 x institutional upper limit of normal (IULN)) or hepatic dysfunction (bilirubin greater than IULN; transaminases greater than 2.5 x IULN) are not eligible. - Except for the following, no prior malignancy is allowed: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient has been disease free for 5 years. - Patients with clinically apparent cardiac disease, or history of same, are not eligible. Patients who are > 60 years of age or who have a history of hypertension must have a MUGA prior to enrollment. LVEF must be normal. - Patients who have received prior chemotherapy or radiotherapy are not eligible. - Patients who are pregnant or breastfeeding are not eligible. Women of child bearing potential must have a serum pregnancy test that is negative and agree to practice adequate contraception. - Patients with active infection are not eligible. - Patients who are known to be infected with HIV, hepatitis B or hepatitis C are not eligible. Testing is not required unless there is a high index of clinical suspicion. - Patients suffering from psychiatric impairment are not eligible. - Patients with known hypersensitivity to trimethoprim or sulfonamides are not eligible.
Gender	Both
Ages	18 Years
Accepts Healthy Volunteers	No
Contacts	Not Provided
Location Countries	United States

Administrative Information[ + expand ][ + ]

NCT Number	NCT00194753
Other Study ID Numbers	18229-A
Has Data Monitoring Committee	No
Information Provided By	University of Washington
Study Sponsor	University of Washington
Collaborators	Amgen Bristol-Myers Squibb
Investigators	Principal Investigator: Georgiana K. Ellis, M.D. University of Washington
Verification Date	September 2012

Locations[ + expand ][ + ]