Caduet (generic: amlodipine and atorvastatin) is a prescription medicine used to treat people with high blood pressure and high cholesterol. It is a single tablet containing two medications, amlodipine (Norvasc) and atorvastatin (Lipitor).
Caduet is a prescription medication used to treat people who have both high blood pressure and high cholesterol.
See "Drug Precautions" for risks associated with Caduet.
Caduet can cause serious side effects including:
- serious muscle problems that can lead to kidney problems, including kidney failure.
- liver problems
- allergic reactions including swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing which may require treatment right away.
Call your doctor right away if you:
- have muscle problems like weakness, tenderness, or pain that happen without a good reason, especially if you also have a fever or feel more tired than usual
- have nausea and vomiting, or stomach pain
- are passing brown or dark-colored urine
- feel more tired than usual
- have yellowing of skin and white of your eyes
- have allergic skin reactions
- have chest pain that does not go away or gets worse.
Sometimes, when you start Caduet or increase your dose, chest pain can get worse or a heart attack can happen. If this happens, call your doctor or go to the emergency room right away.
Common side effects of Caduet include:
- stomach pain
- upset stomach
- swelling of your legs or ankles (edema)
- hot or warm feeling in your face (flushing)
- irregular heartbeat (arrhythmia) very fast heartbeat (heart palpitations)
- muscle and joint pain
- alterations in some laboratory blood tests
- extreme sleepiness
This is not a complete list of Caduet side effects. Ask your doctor or pharmacist for more information.
Some medicines may interact with Caduet. Tell your doctor if you are taking any other prescription or non-prescription medicines, vitamins, or herbal supplements. Especially tell your doctor if you are taking any of the following:
- antifungals (e.g. fluconazole, itraconazole, voriconazole)
- St. John's Wort
- birth control pills
There may be other medicines that interact with Caduet. This is not a complete list of Caduet drug interactions. Check with your doctor before you start, stop, or change the dose of any medicine.
Caduet includes a statin medication called atorvastatin. Statin medications carry a rare but serious risk of:
- liver damage
- memory loss or confusion
- increase in blood sugar levels (hyperglycemia)
- type 2 diabetes
- immune-mediated muscle breakdown
Certain statins can increase risk of muscle weakness as well. It is important to consult your physician to discuss the benefits and risks associated with using this medication.
Do not use Caduet if you are allergic to any ingredient in it. See "Forms of Medication".
Do not use Caduet if you are pregnant or breastfeeding.
Do not take Caduet if you have liver problems.
Caduet may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol.
Eating grapefruit or drinking grapefruit juice may increase the amount of Caduet in your blood, which may increase your risk of serious side effects. Avoid large amounts of grapefruit juice.
Drinking alcohol daily or in large amounts may increase the risk of liver problems with Caduet.
Tell your doctor about all of your health conditions, including, if you have:
- heart disease
- muscle aches or weakness
- thyroid problems
- kidney problems
- or drink more than 2 glasses of alcohol daily
- your immune system
- birth control
- heart failure
- HIV (AIDS)
Tell your doctor if you are pregnant or plan to become pregnant. Do not use Caduet if you are pregnant. It may cause harm to your unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed. You should not use Caduet if you are breastfeeding. It may be excreted in your breast milk and may harm your nursing child.
Caduet comes as a tablet to be taken by mouth, with or without food. It is usually taken once a day, at the same time each day. Caduet tablets should be swallowed whole. Do not break, chew, or crush them. If you miss a dose, take it as soon as you remember. Do not take Caduet if it has been more than 12 hours since your missed dose. Just take the next dose at your regular time. Do not take 2 doses of Caduet at the same time.
Take Caduet exactly as your doctor prescribes it. Follow the directions on your prescription bottle carefully. Your doctor will determine the best dose for you based on the condition being treated, other medical conditions you have, how you respond to this medication as well as other factors.
Caduet is available in several strengths. The recommended dose of amlodipine (Norvasc) is 2.5 mg to 10 mg a day. The recommended dose of atorvastatin is 10 mg to 80 mg a day. The dosage must be individualized.
If you take too much Caduet call your local Poison Control Center or seek emergency medical attention right away.
Caduet 2.5/10 mg tablets
Caduet 2.5/20 mg tablets
Caduet 2.5/40 mg tablets
Caduet 5/10 mg tablets
Caduet 5/20 mg tablets
Caduet 5/40 mg tablets
Caduet 5/80 mg tablets
Caduet 10/10 mg tablets
Caduet 10/40 mg tablets
Caduet 10/80 mg tablets
Active ingredients: amlodipine besylate, atorvastatin calcium
Inactive ingredients: calcium carbonate, croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, polysorbate 80, hydroxypropyl cellulose, purified water, colloidal silicon dioxide (anhydrous), magnesium stearate Film coating: Opadry® II White 85F28751 (polyvinyl alcohol, titanium dioxide, PEG 3000 and talc) or Opadry® II Blue 85F10919 (polyvinyl
- Store Caduet at room temperature, 68 to 77°F (20 to 25°C).
- Do not keep medicine that is out-of-date or that you no longer need.
- Keep Caduet and all medicines out of the reach of children. Keep medicines in places where children cannot get it.