Avycaz

Avycaz is used to treat complicated intra-abdominal infections and complicated urinary tract infections. It should only be used for patients with no or limited other treatment options.

Avycaz Overview

Reviewed: February 25, 2015
Updated: 

Avycaz is a prescription medication used to treat complicated intra-abdominal infections and complicated urinary tract infections, including kidney infections.

It is a single product containing 2 medications: ceftazidime and avibactam. Ceftazidime belongs to a group of antibiotics called cephalosporins. These work by stopping the growth of bacteria. Avibactam belongs to a group of drugs called non-beta-lactam beta-lactamase inhibitors. These work by inhibiting the enzymes in bacteria that provide resistance to antibiotics. In this combination, avibactam allows the ceftazidime to work more effectively.

This medication is available as an injection and is given into the vein (intravenous (IV)) by a healthcare professional.

Common side effects of Avycaz include vomiting, nausea, constipation and anxiety. Avycaz may cause dizziness. Do not drive or operate heavy machinery until you now how Avycaz affects you.

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Avycaz Cautionary Labels

precautions

Uses of Avycaz

Avycaz is a prescription medication used to treat complicated intra-abdominal infections and complicated urinary tract infections, including kidney infections. Avycaz should be given with metronidazole when treating intra-abdominal infections.

Avycaz should only be used in patients with no or limited alternative treatment options.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Avycaz Drug Class

Avycaz is part of the drug class:

Side Effects of Avycaz

Serious side effects have been reported with Avycaz. See the “Avycaz Precautions” section.

Common side effects of Avycaz include the following:

  • vomiting
  • nausea
  • constipation
  • anxiety

This is not a complete list of Avycaz side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Avycaz Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Probenecid (Probalan)

This is not a complete list of Avycaz drug interactions. Ask your doctor or pharmacist for more information.

Avycaz Precautions

Serious side effects have been reported with Avycaz including the following:

  • Hypersensitivity reactions, including anaphylaxis and skin reactions
  • Clostridium difficile-associated diarrhea
  • Central nervous system reactions, including seizures and other neurological events

Avycaz may cause dizziness. Do not drive or operate heavy machinery until you now how Avycaz affects you.

Do not take Avycaz if you:

  • are allergic to Avycaz or to any of its ingredients

Avycaz Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Avycaz, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Avycaz, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Avycaz or to any of its ingedients
  • are allergic to other antibiotics, especially penicillins and cephalosporins
  • have kidney disease
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Avycaz and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X - are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Avycaz falls into category B. In animal studies, pregnant animals were given ceftazidime and avibactam, and some babies had minor problems. There are no well-done studies that have been done in humans with Avycaz.

Avycaz and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Ceftazidime, an ingredient in Avycaz, has been detected in human breast milk. It is not known if avibactam, the other ingredient in Avycaz, crosses into human milk. Because of the possibility for adverse reactions in nursing infants from Avycaz, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Avycaz Usage

Use Avycaz exactly as prescribed.

This medication is available in injectable form to be given directly into a vein (IV) by a healthcare professional.

If you miss a dose,the missed dose should be administered as soon as possible. If it is almost time for the next dose, skip the missed dose and administer the next dose at the regular time. Do not take 2 doses of Avycaz at the same time.

Avycaz Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have

The recommended dose of Avycaz for adults with normal renal function is 2.5 grams administered intravenously every 8 hours. Treatment should continue for up to 14 days, depending on the infection being treated.

Avycaz Overdose

If you take too much Avycaz, call your healthcare provider or local Poison Control Center or seek emergency medical attention right away.

If Avycaz is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Keep this and all medications out of the reacgh of children.