Aranesp treats anemia caused by chronic kidney disease or chemotherapy. Typically your dose will be based on weight.

Aranesp Overview


Aranesp is a prescription medication used to treat a lower than normal number of red blood cells (anemia) caused by chronic kidney disease or chemotherapy. Aranesp belongs to a group of drugs called erythropoiesis-stimulating agents (ESAs). These medications work by causing the soft tissue inside the bones where blood cells are made (bone marrow) to make more red blood cells. 

Aranesp comes in an injectable form that may be given by injection under the skin (subcutaneously) or intravenously (into a vein). It is usually given once every 1 to 4 weeks.
Common side effects of Aranesp include difficulty breathing, cough, and tiredness.  

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Aranesp Cautionary Labels


Uses of Aranesp

Aranesp is a prescription erythropoietin medicine used to treat a lower than normal number of red blood cells (anemia) caused by chronic kidney disease or chemotherapy. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Aranesp Drug Class

Aranesp is part of the drug class:

Side Effects of Aranesp

Using Aranesp can lead to death or other serious side effects.

  • You may get serious heart problems such as heart attack, stroke, heart failure, and may die sooner if you are treated with Aranesp to reach a normal or near-normal hemoglobin level.
  • You may get blood clots at any time while taking Aranesp.

Call your doctor or get medical help right away if you have any of these symptoms of blood clots:

  • Chest pain
  • Trouble breathing or shortness of breath
  • Pain in your legs, with or without swelling
  • A cool or pale arm or leg
  • Sudden confusion, trouble speaking, or trouble understanding others' speech
  • Sudden numbness or weakness in your face, arm, or leg, especially on one side of your body
  • Sudden trouble seeing
  • Sudden trouble walking, dizziness, loss of balance or coordination
  • Loss of consciousness (fainting)
  • Hemodialysis vascular access stops working

Other possible side effects of Aranesp include:

  • High blood pressure is the most common side effect of Aranesp in people with chronic kidney disease.  Your doctor will check your blood pressure often. 
  • Seizures can occur with Aranesp treatment. 
  • Your body may make antibodies to Aranesp that can block or lessen your body's ability to make red blood cells and cause you to have severe anemia. Symptoms to watch for include: unusual tiredness, lack of energy, dizziness, or fainting. 
  • Serious allergic reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness and fainting because of a drop in blood pressure, swelling around your mouth or eyes, fast pulse, or sweating. If you have a serious allergic reaction, stop using Aranesp and call your doctor or get medical help right away. The needle cover on the prefilled syringe contains latex. If you know you are allergic to latex, talk to your doctor before using Aranesp.

Common side effects of Aranesp include:

  • shortness of breath
  • cough
  • low blood pressure during dialysis
  • abdominal pain
  • edema (swelling) of the arms or legs

This is not a complete list of Aranesp side effects. Ask your doctor or pharmacist for more information.

Aranesp Interactions

No Aranesp drug interactions have been identified, however, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Aranesp Precautions

You must be counseled by your doctor regarding the risks of Aranesp and sign the ESA APPRISE Oncology Program Patient and Healthcare Professional (HCP) Acknowledgement Form before you begin to receive Aranesp. 

Do not take Aranesp if you:

  • Have high blood pressure that is not controlled (uncontrolled hypertension). 
  • Have been told by your doctor that you have or have ever had certain types of bleeding or clotting disorders. 
  • Have allergies to any of the ingredients in Aranesp. This includes if you have an allergy to latex. The needle cover on the prefilled syringe contains latex. If you know you are allergic to latex, talk to your doctor before using Aranesp.

Aranesp Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Aranesp there are no specific foods that you must exclude from your diet when receiving Aranesp.

Inform MD

Tell your doctor about all your medical conditions, including if you:

  • Have heart disease. 
  • Have high blood pressure. 
  • Have had a seizure (convulsion) or stroke. 
  • Are allergic to latex.
  • Have any other medical conditions.

Tell your doctor if you are pregnant or breastfeeding.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Aranesp and Pregnancy

Tell your doctor if you are pregnant of if you are planning to become pregnant. It is not known if Aranesp will harm your unborn baby. 

Aranesp and Lactation

Tell your doctor if you are breastfeeding or planning to breastfeed. It is not known if Aranesp is excreted in human breast milk or if it will harm your nursing baby.

Aranesp Usage

Aranesp comes as a liquid to be injected under the skin (subcutaneously) or intravenously (into a vein). This medication is usually given once a week, once every two weeks, or once every three weeks. You will likely start on a low dose of Aranesp. Your doctor will adjust your dose depending on your lab results. Follow these directions carefully.

Aranesp injections may be given by a healthcare provider (doctor or nurse), or your doctor may teach you to give yourself injections. Never shake vials or syringes containing Aranesp. Always inject Aranesp in its own syringe. Do not dilute it with any liquid and do not mix it with any other medications.

When injecting Aranesp choose a new location on your body each time you inject yourself. Choose the outer areas of your upper arms, your stomach, the front of your middle thighs, and the upper, outer areas of your buttocks. If you are being treated with dialysis, your doctor may tell you to inject Aranesp into the port where dialysis tubing is connected to your body.

Aranesp Dosage

If you will be injecting Aranesp yourself, take Aranesp exactly as prescribed. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you based on your medical conditions, your weight, and other factors.

The recommended starting dose for people with chronic kidney disease patients on dialysis is based on weight as follows:

  • 0.45 mcg/kg intravenously (into a vein) or subcutaneously (injection under the skin) weekly, or
  • 0.75 mcg/kg intravenously or subcutaneously every 2 weeks
  • Intravenous route is recommended for people on hemodialysis

Recommended starting dose for patients with chronic kidney disease who are not on dialysis:

  • 0.45 mcg/kg intravenously or subcutaneously at 4 week intervals

Recommended starting dose for cancer patients on chemotherapy:

  • 2.25 mcg/kg subcutaneously weekly until chemotherapy treatments end or
  • 500 mcg subcutaneously every 3 weeks until chemotherapy treatments end

Your doctor will adjust your dose as necessary based on your lab results as well as how you feel and other factors.

Aranesp Overdose

If you take too much Aranesp call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Aranesp is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Do not shake Aranesp.
  • Protect Aranesp from light.
  • Store Aranesp in the refrigerator.
  • Do not freeze Aranesp. Do not use Aranesp that has been frozen.
  • Throw away the Aranesp vial or prefilled syringe after one use. Do not re-use even if there is medicine left.
  • Keep Aranesp and all medicines out of the reach of children.

Aranesp FDA Warning


Chronic Kidney Disease:

  • In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL.
  • No trial has identified a hemoglobin target level, Aranesp dose, or dosing strategy that does not increase these risks.
  • Use the lowest Aranesp dose sufficient to reduce the need for red blood cell (RBC) transfusions.


  • ESAs shortened overall survival and/or increased the risk of tumor progression or recurrence in clinical studies of patients with breast, non-small cell lung, head and neck, lymphoid, and cervical cancers.
  • Prescribers and hospitals must enroll in and comply with the ESA APPRISE Oncology Program to prescribe and/or dispense Aranesp to patients with chemotherapy induced anemia.
  • Use the lowest dose to avoid RBC transfusions.
  • Use ESAs only for anemia from myelosuppressive chemotherapy.
  • ESAs are not indicated for patients receiving myelosuppressive chemotherapy when the anticipated outcome is cure.
  • Discontinue following the completion of a chemotherapy course.