Ampligen Overview

Reviewed: October 21, 2014

Ampligen (rintatolimod) in an investigational anti-viral drug that has been studied as a possible treatment for several conditions, including chronic fatigue syndrome (CFS), certain cancers, HIV/AIDS, swine and avian flu, and Ebola virus.

Ampligen may work by stimulating the immune system to eradicate pathogens by activating the production of an enzyme called RNase L. This enzyme degrades all RNA in a cell (both cellular and viral). Accumulation of an inactive form of RNase L may be associated with CFS. 

This medication comes in an injectable form that is given directly into a vein (IV) twice weekly for at least 12 months. The most commonly used dose in clinical trials has been 400 mg.

Common side effects include flu-like symptoms (chills, fever, tiredness) and flushing.

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