Aliskiren & Valsartan

Aliskiren/valsartan treats high blood pressure. Fatty meals may decrease the amount of medication your body is able to absorb.

Aliskiren & Valsartan Overview

Reviewed: September 5, 2012
Updated: 

Aliskiren/valsartan is a prescription medication used to treat high blood pressure. It is a single tablet containing 2 medications, aliskiren and valsartan. Aliskiren belongs to a group of drugs called renin inhibitors, which work by reducing renin production in the body to reduce blood pressure. Valsartan belongs to a groups of drugs called angiotensin II receptor blockers (ARBs), which work by relaxing blood vessels to lower blood pressure. 

This medication comes in tablet form and is taken once daily. Fatty meals may decrease the amount of aliskiren/valsartan your body is able to absorb. It is important you take aliskiren/valsartan the same way, with or without food, everyday.

Common side effects of aliskiren/valsartan include tiredness, sore throat, runny nose, and diarrhea.

Novartis Pharmaceuticals Corporation has withdrawn Valturna (aliskiren/valsartan) tablets from the U.S. market (as of July 20, 2012).

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Aliskiren & Valsartan Cautionary Labels

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Uses of Aliskiren & Valsartan

Aliskiren/valsartan is a prescription medicine used alone or with other medicines to lower high blood pressure in adults:

  • when one medicine to lower high blood pressure is not enough
  • as the first medicine to lower high blood pressure if your doctor decides that you are likely to need more than one medicine

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Aliskiren & Valsartan Brand Names

Aliskiren & Valsartan may be found in some form under the following brand names:

Aliskiren & Valsartan Drug Class

Aliskiren & Valsartan is part of the drug class:

Side Effects of Aliskiren & Valsartan

Aliskiren/valsartan may cause serious side effects:

  • Injury or death to an unborn baby. See "Drug Precautions" and FDA Warning.
  • Low blood pressure (hypotension). Your blood pressure may get too low if you also take water pills, are on a low-salt diet, get dialysis treatments, have heart problems, or get sick with vomiting or diarrhea. Drinking alcohol and taking certain medicines (barbiturates or narcotics) can cause low blood pressure to get worse. Lie down if you feel faint or dizzy, and call your doctor right away.
  • Angioedema. Aliskiren, a component in this medication, can cause swelling of the face, lips, tongue, throat, arms and legs, or the whole body. Get medical help right away and tell your doctor if you get any one or more of these symptoms. Angioedema can happen at any time while you are taking aliskiren/valsartan .

Common side effects of aliskiren/valsartan include:

  • Tiredness
  • Sore throat
  • Runny nose
  • Diarrhea
  • Upper respiratory tract infection
  • Urinary tract infection
  • Flu or flu-like symptoms
  • Dizziness

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of aliskiren/valsartan. For a complete list of side effects, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Aliskiren & Valsartan Interactions

Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements. Especially tell your doctor if you are taking:

  • other medicines for high blood pressure or a heart problem
  • water pills (also called “diuretics”)
  • medicines for treating fungus or fungal infections
  • cyclosporine (a medicine used to suppress the immune system)
  • potassium-containing medicines, potassium supplements, or salt substitutes containing potassium
  • atorvastatin
  • nonsteroidal anti-inflammatory drugs (like ibuprofen or naproxen)

Your doctor or pharmacist will know what medicines are safe to take together. Know your medicines. Keep a list of your medicines and show it to your doctor or pharmacist when you get a new medicine.

Aliskiren & Valsartan Precautions

You should not take aliskiren/valsartan if:

  • If you get pregnant, stop taking aliskiren/valsartan and call your doctor right away. If you plan to become pregnant, talk to your doctor about other treatment options for your high blood pressure. 
  • Do not take aliskiren/valsartan if you are allergic to any of its ingredients. 

Inform MD

Tell your doctor about all your medical conditions, including whether you:

  • have kidney problems
  • have liver problems
  • have ever had a reaction called angioedema, to another blood pressure medicine. Angioedema causes swelling of the face, lips, tongue, throat, arms and legs, and may cause difficulty breathing.
  • are pregnant or planning to become pregnant. 
  • are breastfeeding. It is not known if aliskiren/valsartan passes into your breast milk.

Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements.

Aliskiren & Valsartan and Pregnancy

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category D. Aliskiren/valsartan can cause harm or death to an unborn baby. Talk to your doctor about other ways to lower your blood pressure if you plan to become pregnant. If you get pregnant while taking aliskiren/valsartan, tell your doctor right away.

 

Aliskiren & Valsartan and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if aliskiren/valsartan is excreted in human milk or if it will harm your nursing baby.

Aliskiren & Valsartan Usage

  • Take aliskiren/valsartan exactly as prescribed by your doctor. It is important to take aliskiren/valsartan every day to control your blood pressure.
  • Take aliskiren/valsartan once each day, about the same time each day.
  • Take aliskiren/valsartan the same way everyday, either with or without a meal.
  • Your doctor may change your dose of aliskiren/valsartan if needed.
  • If you miss a dose of aliskiren/valsartan, take it as soon as you remember. If it is close to your next dose, do not take the missed dose. Just take the next dose at your regular time.
  • If you take too much aliskiren/valsartan, call your doctor or a Poison Control Center, or go to the nearest hospital emergency room.

Aliskiren & Valsartan Overdose

If you take too much aliskiren/valsartan, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If aliskiren/valsartan is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

 

 

Other Requirements

  • Store aliskiren/valsartan tablets at room temperature between 59°F-86°F (15°C-30°C).
  • Keep aliskiren/valsartan in the original prescription bottle in a dry place. Do not remove the desiccant (drying agent) from the bottle.
  • Keep aliskiren/valsartan and all medicines out of the reach of children.

Aliskiren & Valsartan FDA Warning

WARNING: FETAL TOXICITY

  • When pregnancy is detected, discontinue aliskiren/valsartan as soon as possible. 
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.