Akynzeo

Akynzeo prevents nausea and vomiting caused by cancer chemotherapy.

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Akynzeo Overview

Reviewed: October 10, 2014
Updated: 

Akynzeo is a prescription medication used to prevent nausea and vomiting in patients receiving cancer chemotherapy.

Akynzeo is available in capsule form and is taken 1 hour before the start of chemotherapy. It can be taken with or without food.

This medication comes in a single capsule that contains two medications: netupitant and palonosetron. Palonosetron is a serotonin receptor antagonist. This drug prevents nausea and vomiting during the first 24 hours after the start of cancer chemotherapy. Netupitant is a substance P/neurokinin 1 receptor antagonist. This drug prevents nausea and vomiting during both the acute phase(first 24 hours) and delayed phase (from 25 to 120 hours) after the start of cancer chemotherapy.

Common side effects of Akynzeo include headache, weakness, fatigue, indigestion and constipation.

Akynzeo can also cause dizziness. Do not drive or operate heavy machinery until you know how Akynzeo affects you.

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Uses of Akynzeo

Akynzeo is a prescription medication used to prevent nausea and vomiting in patients receiving cancer chemotherapy.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Akynzeo Drug Class

Akynzeo is part of the drug class:

Side Effects of Akynzeo

Serious side effects have been reported with Akynzeo. See the “Akynzeo Precautions” section.

Common side effects of Akynzeo include

  • headache
  • weakness
  • fatigue
  • indigestion
  • constipation

This is not a complete list of side effects Akynzeo side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Akynzeo Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • benzodiazepines including alprazolam (Xanax), midazolam, and triazolam (Halcion)
  • certain chemotherapy medications such as cyclophosphamide (Cytoxan), docetaxel (Docefrez, Taxotere), etoposide, ifosfamide (Ifex), imatinib (Gleevec), irinotecan (Camptosar), paclitaxel (Taxol), vinblastine, vincristine, and vinorelbine (Navelbine)
  • dexamethasone
  • erythromycin (E.E.S., Ery-tab, others)
  • fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys)
  • ketoconazole (Nizoral)
  • lithium (Lithobid)
  • medications to treat migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig)
  • methylene blue
  • mirtazapine (Remeron)
  • monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate)
  • phenobarbital
  • rifampin (Rifadin, Rimactane, in Rifater, in Rifamate)
  • selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft)
  • tramadol (Conzip, Ultram, in Ultracet)

This is not a complete list of Akynzeo drug interactions. Ask your doctor or pharmacist for more information.

Akynzeo Precautions

Serious side effects have been reported with Akynzeo including the following:

  • hypersensitivity reactions, including anaphylaxis
  • serotonin syndrome. Tell your healthcare provider right away if you have some or all of the following symptoms of serotonin syndrome:
    • changes in mental status, including agitation, hallucination, delirium, or coma
    • increased heart rate
    • changes in blood pressure
    • dizziness
    • flushing
    • neuromuscular symptoms, including tremor, muscle rigidity, or incoordination
    • seizures

Akynzeo can cause dizziness. Do not drive or operate heavy machinery until you know how Akynzeo affects you.

Do not take Akynzeo if you:

  • are allergic to Akynzeo or to any of its ingredients

Akynzeo Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Akynzeo, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Akynzeo, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Akynzeo or to any of its ingredients
  • have or have had liver disease
  • have or have had kidney disease
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Akynzeo and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X - are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Akynzeo falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Akynzeo and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Akynzeo crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Akynzeo.

Akynzeo Usage

Take Akynzeo exactly as prescribed.

Akynzeo is available in capsule form and is taken 1 hour before the start of chemotherapy. It can be taken with or without food.

Akynzeo Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated

The recommended dose of Akynzeo is one capsule (300 mg netupitant/0.5mg palonosetron) approximately 1 hour before chemotherapy. It is usually administered with dexamethasone.

Akynzeo Overdose

If you take too much Akynzeo, call your healthcare provider or local Poison Control Center or seek emergency medical attention right away.

If Akynzeo is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Akynzeo at room temperature.
  • Keep this and all medications out of the reach of children.